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Protein

Catalase-peroxidase

Gene

katG

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei94Transition state stabilizerUniRule annotation1
Active sitei98Proton acceptorUniRule annotation1
Metal bindingi260Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-617-MONOMER

Protein family/group databases

PeroxiBasei3652 RpCP01_HaA2

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:RPB_0610
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548961 – 732Catalase-peroxidaseAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97 ↔ 219Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-245)UniRule annotation
Cross-linki219 ↔ 245Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ2J2I9

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_0610

Structurei

3D structure databases

SMRiQ2J2I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q2J2I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKTDDKDG GKCPFPHGGG RGRRNSDWWP EHLDISLLHR NSTLSDPMGK
60 70 80 90 100
GFDYAREFES LDLDAVIKDL HALMTDSQDW WPADFGHYGG LMVRMAWHSA
110 120 130 140 150
GTYRTTDGRG GAGAGQQRFA PLNSWPDNAN LDKARRLLWP IKQKYGNKIS
160 170 180 190 200
WADLYVLTGN VALESMGFKT FGFAGGRADT WEPEELFWGP EGSWLGDERY
210 220 230 240 250
SGERELSDPL GAVQMGLIYV NPEGPNGNPD PVAAAKDIRE TFARMAMNDE
260 270 280 290 300
ETVALIAGGH TFGKTHGAGD PSLIGAEPEG GALEDQGLGW KSSFGTGFGA
310 320 330 340 350
DAITGGPEVI WTQTPTQWSN HFFENLFGFE WELDKSPAGA KQWKAKGAEA
360 370 380 390 400
NIPDPFDPTK KRLPTMLTTD LSLRFDPAYE KISRRFLENP DQFADAFARA
410 420 430 440 450
WFKLTHRDMG PKVRYRGKLV PKEDLIWQDP IPPVDHELVG DKDIAALKAK
460 470 480 490 500
ILGSGLSVSQ LVSAAFASAS TYRHSDKRGG ANGARIRFAP QKDWEVNQPS
510 520 530 540 550
DLAQVLSKLE AIQKEFNGAQ TDGKKVSLAD LIVLGGCAAV EKAAKDAGTD
560 570 580 590 600
IQVPFTPGRM DALEEQTDAD SFKVLEPRAD GFRNFIGKRK QYMSPEESLV
610 620 630 640 650
DRAQLLNLTA PEMTALLGGL RVLGGNVGHT THGVFTERPE KLTNDFFVNL
660 670 680 690 700
LDMKTAWSPS ATTEVVYEGR DRKTGELRWT GTRVDLIFGS HSQLRALAEV
710 720 730
YAQSDAQPKF ARDFVAAWTK VMNADRFDIV AK
Length:732
Mass (Da):80,663
Last modified:March 7, 2006 - v1
Checksum:i8C58B74ED4DCC0EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD05321.1
RefSeqiWP_011439511.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD05321; ABD05321; RPB_0610
KEGGirpb:RPB_0610

Similar proteinsi

Entry informationi

Entry nameiKATG_RHOP2
AccessioniPrimary (citable) accession number: Q2J2I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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