true2008-01-152024-01-24106FPG_RHOP2Complete sequence of Rhodopseudomonas palustris HaA2.Copeland A.Lucas S.Lapidus A.Barry K.Detter J.C.Glavina T.Hammon N.Israni S.Pitluck S.Chain P.Malfatti S.Shin M.Vergez L.Schmutz J.Larimer F.Land M.Hauser L.Pelletier D.A.Kyrpides N.Anderson I.Oda Y.Harwood C.S.Richardson P.US DOE Joint Genome Institute2006-01EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]HaA2BacteriaEcFpg-like_NMutM-like, N-terminalFapy_DNA_glycosylDNA_glyclase/AP_lyase_DNA-bdDNA_glyclase_Znf_dom_DNA_BSFormamido-pyr_DNA_GlyclaseFPG_catMutM-like_N-terRibosomal_uS13-like_H2THZnf_DNA_glyclase/AP_lyasefpgFORMAMIDOPYRIMIDINE-DNA GLYCOSYLASEFORMAMIDOPYRIMIDINE-DNA GLYCOSYLASEFapy_DNA_glycoH2THFapy_DNA_glycoH2THGlucocorticoid receptor-like (DNA-binding domain)N-terminal domain of MutM-like DNA repair proteinsS13-like H2TH domainFPG_CATZF_FPG_1ZF_FPG_2Formamidopyrimidine-DNA glycosylaseFapy-DNA glycosylase3.2.2.23DNA-(apurinic or apyrimidinic site) lyase MutMAP lyase MutM4.2.99.18mutMfpgRPB_0619Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.Binds 1 zinc ion per subunit.Monomer.Belongs to the FPG family.Removed1Formamidopyrimidine-DNA glycosylase318942293FPG-type257Schiff-base intermediate with DNAProton donor3Proton donor; for beta-elimination activity58Proton donor; for delta-elimination activity2831041231662006-03-07132026906cb1115388ab302d9f8ef29da39063MPELPEVETVRLGLQPAMEGFRIDRAMANRCDLRFPFQPDFAARLTGQTITGLGRRAKYLLADLSSGDVLLMHLGMSGSFRVVNGAGDATPGEFHHPRSEDRTHDHVVFEMSSGARVIFNDPRRFGFMKIFARAAIDDEPHLKGLGPEPLGNAFDAAMLARACAGKQTSLKAALLDQRVVAGLGNIYVCEALWRAHLSPKRKASTLADRKGAPTDRAVRLVDAIRAVLGDAIKAGGSSLRDHRQTSGELGYFQHSFAVYDREGERCRTPGCNGTVKRLVQNGRSTFWCSGCQTtruetrue