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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-642-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:RPB_0635
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000958091 – 404Tryptophan synthase beta chainAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_0635

Structurei

3D structure databases

SMRiQ2J2G4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CG0 Bacteria
COG0133 LUCA
HOGENOMiHOG000161710
KOiK01696
OMAiHGMKSYF
OrthoDBiPOG091H02JY

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2J2G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQILPNSFR SGPDERGHFG IFGGRFVAET LMPLILALEK AYAEAKDDPA
60 70 80 90 100
FRAEMDGYLK HYVGRPSPLY FAERLTEHFG GAKIYFKRED LNHTGAHKVN
110 120 130 140 150
NVLGQIMLAR RMGKPRIIAE TGAGMHGVAT ATMCAKFGLQ CVVYMGAVDV
160 170 180 190 200
DRQQPNVLRM KALGAEVRPV TSGAATLKDA MNEALRDWVT NVHDTFYCIG
210 220 230 240 250
TVAGPHPYPM MVRDFQAVIG QEVRAQIMEA EGRLPDSLIA CIGGGSNAMG
260 270 280 290 300
LFHPFLDDSS VAIYGVEAAG HGLSKLHAAS IAGGKPGVLH GNRTYLLMDT
310 320 330 340 350
DGQIQEAHSI SAGLDYPGIG PEHAWLHDVG RVEFMSATDT EALDAFKLCC
360 370 380 390 400
RLEGIIPALE PAHALAKVGD LAPPLPKDHV MVLNMSGRGD KDLASVAEHL

GGQF
Length:404
Mass (Da):43,539
Last modified:March 7, 2006 - v1
Checksum:i29D59580D0886D17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD05346.1
RefSeqiWP_011439536.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD05346; ABD05346; RPB_0635
KEGGirpb:RPB_0635

Similar proteinsi

Entry informationi

Entry nameiTRPB_RHOP2
AccessioniPrimary (citable) accession number: Q2J2G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health