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Q2J2D8

- UPPP_RHOP2

UniProt

Q2J2D8 - UPPP_RHOP2

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, RPB_0661
Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciRPAL316058:GHF1-673-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:RPB_0661
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000008809: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST
Transmembranei47 – 6721Helical; Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Reviewed prediction
Add
BLAST
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Transmembranei246 – 26621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Undecaprenyl-diphosphataseUniRule annotation
PRO_0000250257Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_0661.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2J2D8-1 [UniParc]FASTAAdd to Basket

« Hide

MLSDIIRAVI LGVVEGVTEF LPVSSTGHLL LVGRFFNLGE GDFWKTFDVL    50
IQLGAILAIL ALYFAKLWRI ALGMFSDPAA QRFIIGVLVA FLPAAVIGAA 100
AGSYIKLFLF NPWVVCFSLI VGGAVLLWVD QLDLKPRHHD ATTFPVLMYF 150
YIGCAQCVAM IPGVSRSGAS IVAAMLFGAD KRAAAEFSFF LAIPTMVGAF 200
VYDLYKSRAD LTTDHMTIVA VGFVVSFITA IIVVKTFLGY VTRHGFQLFA 250
WWRVVVGTLG LIALAMGR 268
Length:268
Mass (Da):29,156
Last modified:March 7, 2006 - v1
Checksum:i9B0EEF7E7923FFE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD05372.1.
RefSeqiWP_011439562.1. NC_007778.1.
YP_484283.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD05372; ABD05372; RPB_0661.
GeneIDi3908588.
KEGGirpb:RPB_0661.
PATRICi23295795. VBIRhoPal125544_0696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD05372.1 .
RefSeqi WP_011439562.1. NC_007778.1.
YP_484283.1. NC_007778.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 316058.RPB_0661.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD05372 ; ABD05372 ; RPB_0661 .
GeneIDi 3908588.
KEGGi rpb:RPB_0661.
PATRICi 23295795. VBIRhoPal125544_0696.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci RPAL316058:GHF1-673-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HaA2.

Entry informationi

Entry nameiUPPP_RHOP2
AccessioniPrimary (citable) accession number: Q2J2D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi