ID   HGD_RHOP2               Reviewed;         448 AA.
AC   Q2J1P2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   05-MAY-2009, entry version 21.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=RPB_0907;
OS   Rhodopseudomonas palustris (strain HaA2).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A.,
RA   Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris HaA2.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; CP000250; ABD05618.1; -; Genomic_DNA.
DR   RefSeq; YP_484529.1; -.
DR   GeneID; 3909087; -.
DR   GenomeReviews; CP000250_GR; RPB_0907.
DR   KEGG; rpb:RPB_0907; -.
DR   HOGENOM; Q2J1P2; -.
DR   OMA; Q2J1P2; HRNCMSE.
DR   BioCyc; RPAL316058:RPB_0907-MON; -.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    448       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000019540.
FT   METAL       346    346       Iron (By similarity).
FT   METAL       352    352       Iron (By similarity).
FT   METAL       382    382       Iron (By similarity).
SQ   SEQUENCE   448 AA;  49544 MW;  55E2497583E035F0 CRC64;
     MNINAAPQII GHGSQGVTPG YMSGFGNSFE TEALPGALPI GRNSPQRAAY GLYAEQLSGS
     PFTAPRGANE RSWLYRIRPS VKHSGRFTKA DMGLWRSAPC LEYDMPIAQL RWDAPSMPQE
     DLTFLQGVRT MTTAGDVNTQ AGMATHMYLI TQSMVDQHFY NADGELMFVP QQGSLRLVTE
     FGVISIEPAE IAVIPRGVKF RVELVDGPAR GYLCENYGGA FTLPERGPIG ANCLANSRDF
     LTPVAAYEDR DVPTELFVKW GGALWQTTLP HSPIDVVAWH GNYAPYKYDL RTFSPVGAIG
     FDHPDPSIFT VLTSPSETAG TANIDFVIFP ERWMVAENTF RPPWYHMNIM SEFMGLICGV
     YDAKPQGFVP GGASLHNMML PHGPDREAFD HASNGELKPV KLTGTMAFMF ETRYPQRVTE
     YAATAGTLQD DYADCWRGLE KRFDPSRP
//