Reviewed, UniProtKB/Swiss-Prot Q2J1P2 (HGD_RHOP2)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	RPB_0907

Organism

Rhodopseudomonas palustris (strain HaA2) [Complete proteome] [HAMAP]

Taxonomic identifier

316058 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_1000019540
Sites
	Metal binding	346	1	Iron By similarity
	Metal binding	352	1	Iron By similarity
	Metal binding	382	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2J1P2-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 55E2497583E035F0	FASTA	448	49,544
	10 20 30 40 50 60 MNINAAPQII GHGSQGVTPG YMSGFGNSFE TEALPGALPI GRNSPQRAAY GLYAEQLSGS 70 80 90 100 110 120 PFTAPRGANE RSWLYRIRPS VKHSGRFTKA DMGLWRSAPC LEYDMPIAQL RWDAPSMPQE 130 140 150 160 170 180 DLTFLQGVRT MTTAGDVNTQ AGMATHMYLI TQSMVDQHFY NADGELMFVP QQGSLRLVTE 190 200 210 220 230 240 FGVISIEPAE IAVIPRGVKF RVELVDGPAR GYLCENYGGA FTLPERGPIG ANCLANSRDF 250 260 270 280 290 300 LTPVAAYEDR DVPTELFVKW GGALWQTTLP HSPIDVVAWH GNYAPYKYDL RTFSPVGAIG 310 320 330 340 350 360 FDHPDPSIFT VLTSPSETAG TANIDFVIFP ERWMVAENTF RPPWYHMNIM SEFMGLICGV 370 380 390 400 410 420 YDAKPQGFVP GGASLHNMML PHGPDREAFD HASNGELKPV KLTGTMAFMF ETRYPQRVTE 430 440 YAATAGTLQD DYADCWRGLE KRFDPSRP

References

[1]

"Complete sequence of Rhodopseudomonas palustris HaA2." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A. , Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000250 Genomic DNA. Translation: ABD05618.1.
RefSeq	YP_484529.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3909087.
GenomeReviews	Gene locus RPB_0907 in contig CP000250_GR.
KEGG	rpb:RPB_0907.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2J1P2.
OMA	Q2J1P2. HRNCMSE.
Enzyme and pathway databases
BioCyc	RPAL316058:RPB_0907-MON.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_RHOP2

Accession

Primary (citable) accession number: Q2J1P2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	May 5, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)