Q2J0J8 (AROE_RHOP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	RPB_1302

Organism

Rhodopseudomonas palustris (strain HaA2) [Complete proteome] [HAMAP]

Taxonomic identifier

316058 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP-Rule MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP-Rule MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway shikimate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Shikimate dehydrogenase HAMAP-Rule MF_00222		PRO_1000021321
Regions
	Nucleotide binding	131 – 135	5	NADP By similarity
Sites
	Active site	71	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2J0J8 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: C34B059DDD174A25	FASTA	280	29,776
	10 20 30 40 50 60 MHPGDGHTAA CLIGWPAAHS RSPLIHHYWL RTLGIPGGYS IESVPPEGFA EFVLNLRAHG 70 80 90 100 110 120 YSGANVTIPH KERALQLTQP DDRARAVGAA NTLYYDGDVL RSTNTDVEGF IANLDASAPG 130 140 150 160 170 180 WDRTPHAVVL GAGGSARAVL FGLLERGIER IALANRSLER AQALADLFGE RVVPIAWTDA 190 200 210 220 230 240 PAALPGAGLL VNTTSLGMKG QPSLDLDLEP LPSDATVADL VYVPLETELL AEARGRGLRT 250 260 270 280 ADGLGMLLHQ AVRGFELWFG ARPHVTAELR ALVEADLAAK

References

[1]

"Complete sequence of Rhodopseudomonas palustris HaA2." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A. , Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HaA2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000250 Genomic DNA. Translation: ABD06012.1.
RefSeq	YP_484923.1. NC_007778.1.
3D structure databases
HSSP	HSSP built from PDB template 2GPT based on UniProtKB Q9SQT8.
ProteinModelPortal	Q2J0J8.
ModBase	Search...
Protein-protein interaction databases
STRING	316058.RPB_1302.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD06012; ABD06012; RPB_1302.
GeneID	3908175.
KEGG	rpb:RPB_1302.
PATRIC	23297165. VBIRhoPal125544_1378.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HOG000237875.
KO	K00014.
OMA	MAGHPPL.
ProtClustDB	CLSK820486.
Enzyme and pathway databases
BioCyc	RPAL316058:GHF1-1362-MONOMER.
UniPathway	UPA00053; UER00087.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_00222. Shikimate_DH_AroE.
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_RHOP2

Accession

Primary (citable) accession number: Q2J0J8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program