Q2J0F9 (KHSE_RHOP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	RPB_1341

Organism

Rhodopseudomonas palustris (strain HaA2) [Complete proteome] [HAMAP]

Taxonomic identifier

316058 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homoserine kinase HAMAP MF_00301		PRO_0000300806

Sequences

	Sequence		Length	Mass (Da)
	Q2J0F9 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 135EBD21B1FA6F46	FASTA	326	35,832
	10 20 30 40 50 60 MAVYTDVAAD DLADFLKSYE IGDLLSYKGI AEGVENTNFL LHTTRGSFIL TLYEKRVASE 70 80 90 100 110 120 DLPYFLALMA HLAARGVSCP QPEKTRDGEI CGALSGRPAV IINFLEGVWP RRPNAVHCAG 130 140 150 160 170 180 VGEALAKMHL AGLDFPQHRA NPLSVSGWRP LFDLAAARAD EIQPGLRDFI AAELDHLEGR 190 200 210 220 230 240 WPRHLPTGVI HADLFPDNVF FIGDTLSGLI DFPFSCNDIL AYDVAICLNA WCFEPDHAFN 250 260 270 280 290 300 VTKARALLNA YQRGRALSEA EQTALPLLAR GAAMRFLLTR LVDVLDVPEG ALVKPKDPLE 310 320 YFRKLRFQQN VASIRDYGVE AAGAVA

References

[1]

"Complete sequence of Rhodopseudomonas palustris HaA2." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A. , Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HaA2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000250 Genomic DNA. Translation: ABD06051.1.
RefSeq	YP_484962.1. NC_007778.1.
3D structure databases
ProteinModelPortal	Q2J0F9.
SMR	Q2J0F9. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2J0F9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3907849.
GenomeReviews	Gene locus RPB_1341 in contig CP000250_GR.
KEGG	rpb:RPB_1341.
PATRIC	23297247. VBIRhoPal125544_1419.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	RPAL316058:RPB_1341-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RHOP2

Accession

Primary (citable) accession number: Q2J0F9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program