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Protein

Ribonuclease H

Gene

rnhA

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20Magnesium 1UniRule annotation1
Metal bindingi20Magnesium 2UniRule annotation1
Metal bindingi58Magnesium 1UniRule annotation1
Metal bindingi80Magnesium 1UniRule annotation1
Metal bindingi144Magnesium 2UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HUniRule annotation
Gene namesi
Name:rnhAUniRule annotation
Ordered Locus Names:RPB_1342
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003326681 – 161Ribonuclease HAdd BLAST161

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_1342

Structurei

3D structure databases

ProteinModelPortaliQ2J0F8
SMRiQ2J0F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 152RNase HUniRule annotationAdd BLAST142

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UMW Bacteria
COG0328 LUCA
HOGENOMiHOG000040465
KOiK03469
OMAiMQEIEIF
OrthoDBiPOG091H04XT

Family and domain databases

CDDicd09278 RNase_HI_prokaryote_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00042 RNase_H, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR022892 RNaseHI
PfamiView protein in Pfam
PF00075 RNase_H, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit

Sequencei

Sequence statusi: Complete.

Q2J0F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGALSEAGA GPRPVVIHTD GACSGNPGPG GWGAILKFGD TEKELKGGEA
60 70 80 90 100
HTTNNRMELL AAISALEALT RPCTVDLYTD SQYVKNGIGS WIHNWKRNGW
110 120 130 140 150
KTADKKPVKN VDLWQRLDAA LKSHQVRWHW VKGHAGHDEN ERADQLARDG
160
LTENRMKSRI G
Length:161
Mass (Da):17,661
Last modified:March 7, 2006 - v1
Checksum:iA37FC5F2404D95C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD06052.1

Genome annotation databases

EnsemblBacteriaiABD06052; ABD06052; RPB_1342
KEGGirpb:RPB_1342

Similar proteinsi

Entry informationi

Entry nameiRNH_RHOP2
AccessioniPrimary (citable) accession number: Q2J0F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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