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Q2J0A5

- MASZ_RHOP2

UniProt

Q2J0A5 - MASZ_RHOP2

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Protein
Malate synthase G
Gene
glcB, RPB_1395
Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei273 – 2731Acetyl-CoA By similarity
Binding sitei310 – 3101Acetyl-CoA By similarity
Active sitei337 – 3371Proton acceptor By similarity
Binding sitei337 – 3371Glyoxylate By similarity
Metal bindingi429 – 4291Magnesium By similarity
Binding sitei429 – 4291Glyoxylate By similarity
Metal bindingi457 – 4571Magnesium By similarity
Binding sitei538 – 5381Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei628 – 6281Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRPAL316058:GHF1-1413-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:RPB_1395
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000008809: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Malate synthase GUniRule annotation
PRO_1000056923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei614 – 6141Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_1395.

Structurei

3D structure databases

ProteinModelPortaliQ2J0A5.
SMRiQ2J0A5. Positions 2-717.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1252Acetyl-CoA binding By similarity
Regioni454 – 4574Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2J0A5-1 [UniParc]FASTAAdd to Basket

« Hide

MNRIDAHGLK IAPVLFDFIA KEAAPKTGVA PDAFWAGLAA IVRDLTPKTV    50
ALLQHRDGLQ AKIDAWHLAN KGKKQDMAAY TAFLKEIGYL LPEPPTVAVE 100
TANVDDEIGK LCGPQLVVPL SNARYALNAA NARWGSLYDA FYGTDAIPQE 150
ASQAKGYDKA RGDKVIAKAK AFLDQAAPLV AGSHSDVTAY SVIAGQLSAK 200
LKSGNATGLK TPRQFAGYLG DAASPSAVLL VNNGLHIEIK IDRANTIGKD 250
DAAGVADLVI ESAVSTILDM EDSVAAVDAE DKVLIYRNTL GLMDGTLSAD 300
FDKGGKTVTR ALNGDRTYTG PDGKDVTLHG RSLLLMRNVG HHMWTDAVLD 350
SNGDEIPEGF LDAAVSGLLA IHDLKALGKT RNSRTGSVYI VKPKMHGPDE 400
VALTCELFGR VEQMLGLKEN TLKVGIMDEE RRTTVNLKAC IQNASKRIVF 450
INTGFLDRTG DEIHTSMEAG PMIRKNEMKA QPWIKAYEDW NVDTGLIDGL 500
PGHAQIGKGM WAAPDKMADM LTQKIGHPQA GATTAWVPSP TAATLHALHY 550
HQVDVLARQQ ELKTGGPRAK LEDILTIPVS QSNWAPDDVR QEIDNNCQGI 600
LGYVVRWIDQ GVGCSKVPDI HDVGLMEDRA TLRISSQHLA NWLHHGVVTK 650
EQVLESLKRM AAVVDKQNAG DPLYRPMAPD FDGVAFEAAC DLIFKGREQP 700
NGYTEFILHI RRREAKAAHL QDLT 724
Length:724
Mass (Da):78,443
Last modified:March 7, 2006 - v1
Checksum:i2D5D28519CD7EE0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD06105.1.
RefSeqiYP_485016.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD06105; ABD06105; RPB_1395.
GeneIDi3908345.
KEGGirpb:RPB_1395.
PATRICi23297357. VBIRhoPal125544_1474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD06105.1 .
RefSeqi YP_485016.1. NC_007778.1.

3D structure databases

ProteinModelPortali Q2J0A5.
SMRi Q2J0A5. Positions 2-717.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316058.RPB_1395.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD06105 ; ABD06105 ; RPB_1395 .
GeneIDi 3908345.
KEGGi rpb:RPB_1395.
PATRICi 23297357. VBIRhoPal125544_1474.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci RPAL316058:GHF1-1413-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HaA2.

Entry informationi

Entry nameiMASZ_RHOP2
AccessioniPrimary (citable) accession number: Q2J0A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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