Q2IZ89 (GLPK_RHOP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	RPB_1763

Organism

Rhodopseudomonas palustris (strain HaA2) [Complete proteome] [HAMAP]

Taxonomic identifier

316058 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Glycerol kinase HAMAP MF_00186		PRO_1000020765
Regions
	Nucleotide binding	411 – 415	5	ATP By similarity
Sites
	Binding site	11	1	Substrate By similarity
	Binding site	15	1	ATP By similarity
	Binding site	81	1	Substrate By similarity
	Binding site	133	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity
	Binding site	264	1	ATP By similarity
	Binding site	307	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2IZ89 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 6CACAFB420C46D45	FASTA	501	54,057
	10 20 30 40 50 60 MPFVMAIDQG TTSSRAILFR GDISIAASAQ QEFPQHFPAS GWVEHEPEDI WASTLATCRA 70 80 90 100 110 120 AMEKAGATAA DIAAIGITNQ RETVVVWDAA SGKAIHRAIV WQDRRTAEVC TRMKADGYEP 130 140 150 160 170 180 MITDKTGLII DPYFSGTKVA WLLDNVPGAR ARAERGELKF GTIDCWLLWR LTGGRVHATD 190 200 210 220 230 240 ATNASRTLLF NIHTGDWDDE LLQLLRVPRS MLPEVKDSSA HFGDSAYELF GAPIAIRGIA 250 260 270 280 290 300 GDQQAATIGQ ACFSPGMIKS TYGTGCFALL ITGATPVKSH NKLLTTIAYQ LGGKRTYALE 310 320 330 340 350 360 GSIFVAGSAV QWLRDGLGII KHASETGPLA DKSDSMQSVY LVPAFVGLGA PYWNPRVRGA 370 380 390 400 410 420 LFGMTRNTGP AELAHAALES VCYQTYDLWA AMRADWSGAD AAPPVLRVDG GMAASDWTMQ 430 440 450 460 470 480 RLADLLDAPV DRPVIQETTA LGAAYLAGLS AGVFPEPQKF ADNWRLDHRF RPAMSQATRE 490 500 RKLAGWGRAV KGLLASDEGE G

References

[1]

"Complete sequence of Rhodopseudomonas palustris HaA2." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A. , Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HaA2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000250 Genomic DNA. Translation: ABD06471.1.
RefSeq	YP_485382.1. NC_007778.1.
3D structure databases
ProteinModelPortal	Q2IZ89.
SMR	Q2IZ89. Positions 3-494.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IZ89.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3909750.
GenomeReviews	Gene locus RPB_1763 in contig CP000250_GR.
KEGG	rpb:RPB_1763.
PATRIC	23298119. VBIRhoPal125544_1853.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0554.
HOGENOM	HBG511469.
OMA	CYQTRDL.
PhylomeDB	Q2IZ89.
ProtClustDB	CLSK818559.
Enzyme and pathway databases
BioCyc	RPAL316058:RPB_1763-MONOMER.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_RHOP2

Accession

Primary (citable) accession number: Q2IZ89

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program