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Q2IYG6

- Q2IYG6_RHOP2

UniProt

Q2IYG6 - Q2IYG6_RHOP2

Protein

Dihydrofolate reductase

Gene

RPB_2037

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

    Catalytic activityi

    5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. dihydrofolate reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glycine biosynthetic process Source: InterPro
    2. nucleotide biosynthetic process Source: InterPro
    3. one-carbon metabolic process Source: UniProtKB-KW
    4. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    One-carbon metabolismUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciRPAL316058:GHF1-2060-MONOMER.
    UniPathwayiUPA00077; UER00158.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
    Gene namesi
    Ordered Locus Names:RPB_2037Imported
    OrganismiRhodopseudomonas palustris (strain HaA2)Imported
    Taxonomic identifieri316058 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000008809: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi316058.RPB_2037.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dihydrofolate reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0262.
    HOGENOMiHOG000040233.
    KOiK00287.
    OMAiFKALTMG.
    OrthoDBiEOG6KT2V2.

    Family and domain databases

    Gene3Di3.40.430.10. 1 hit.
    InterProiIPR012259. DHFR.
    IPR024072. DHFR-like_dom.
    IPR017925. DHFR_CS.
    IPR001796. DHFR_dom.
    [Graphical view]
    PfamiPF00186. DHFR_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000194. DHFR. 1 hit.
    PRINTSiPR00070. DHFR.
    SUPFAMiSSF53597. SSF53597. 1 hit.
    PROSITEiPS00075. DHFR_1. 1 hit.
    PS51330. DHFR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2IYG6-1 [UniParc]FASTAAdd to Basket

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    MSSPGVSSRL SIVLIVAVAD NGVIGRDNAI PWRLKSDLQR FKQLTLNKPI    50
    IMGRKTYQSI GRPLPGRTNI VVTRDPTFHA DGVVVVPSFD AAEQVACGDA 100
    MRRFATEIAV IGGAEIYAHW LPRATRIELT EVHASPPGDA TFPALDPSQW 150
    EETARTHHAA GPQDSADVSY VTYRRCTAR 179
    Length:179
    Mass (Da):19,532
    Last modified:March 7, 2006 - v1
    Checksum:iDE7E53E1325F87FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000250 Genomic DNA. Translation: ABD06744.1.
    RefSeqiWP_011440932.1. NC_007778.1.
    YP_485655.1. NC_007778.1.

    Genome annotation databases

    EnsemblBacteriaiABD06744; ABD06744; RPB_2037.
    GeneIDi3909852.
    KEGGirpb:RPB_2037.
    PATRICi23298683. VBIRhoPal125544_2135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000250 Genomic DNA. Translation: ABD06744.1 .
    RefSeqi WP_011440932.1. NC_007778.1.
    YP_485655.1. NC_007778.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316058.RPB_2037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD06744 ; ABD06744 ; RPB_2037 .
    GeneIDi 3909852.
    KEGGi rpb:RPB_2037.
    PATRICi 23298683. VBIRhoPal125544_2135.

    Phylogenomic databases

    eggNOGi COG0262.
    HOGENOMi HOG000040233.
    KOi K00287.
    OMAi FKALTMG.
    OrthoDBi EOG6KT2V2.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00158 .
    BioCyci RPAL316058:GHF1-2060-MONOMER.

    Family and domain databases

    Gene3Di 3.40.430.10. 1 hit.
    InterProi IPR012259. DHFR.
    IPR024072. DHFR-like_dom.
    IPR017925. DHFR_CS.
    IPR001796. DHFR_dom.
    [Graphical view ]
    Pfami PF00186. DHFR_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000194. DHFR. 1 hit.
    PRINTSi PR00070. DHFR.
    SUPFAMi SSF53597. SSF53597. 1 hit.
    PROSITEi PS00075. DHFR_1. 1 hit.
    PS51330. DHFR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HaA2Imported.

    Entry informationi

    Entry nameiQ2IYG6_RHOP2
    AccessioniPrimary (citable) accession number: Q2IYG6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3