Q2IYG6 (Q2IYG6_RHOP2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydrofolate reductase PIRNR PIRNR000194
EC=1.5.1.3 PIRNR PIRNR000194

Gene names

Ordered Locus Names:

RPB_2037

Organism

Rhodopseudomonas palustris (strain HaA2) [Complete proteome] [HAMAP] EMBL ABD06744.1

Taxonomic identifier

316058 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity. PIRNR PIRNR000194
Catalytic activity	5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH. PIRNR PIRNR000194
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis. PIRNR PIRNR000194
Sequence similarities	Belongs to the dihydrofolate reductase family. RuleBase RU004474 PIRNR PIRNR000194

Ontologies

Keywords
Biological process	One-carbon metabolism PIRNR PIRNR000194
Ligand	NADP PIRNR PIRNR000194
Molecular function	Oxidoreductase PIRNR PIRNR000194 EMBL ABD06744.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine biosynthetic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro dihydrofolate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2IYG6 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: DE7E53E1325F87FC	FASTA	179	19,532
	10 20 30 40 50 60 MSSPGVSSRL SIVLIVAVAD NGVIGRDNAI PWRLKSDLQR FKQLTLNKPI IMGRKTYQSI 70 80 90 100 110 120 GRPLPGRTNI VVTRDPTFHA DGVVVVPSFD AAEQVACGDA MRRFATEIAV IGGAEIYAHW 130 140 150 160 170 LPRATRIELT EVHASPPGDA TFPALDPSQW EETARTHHAA GPQDSADVSY VTYRRCTAR

References

[1]

"Complete sequence of Rhodopseudomonas palustris HaA2." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A. , Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HaA2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000250 Genomic DNA. Translation: ABD06744.1.
RefSeq	YP_485655.1. NC_007778.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	316058.RPB_2037.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD06744; ABD06744; RPB_2037.
GeneID	3909852.
KEGG	rpb:RPB_2037.
PATRIC	23298683. VBIRhoPal125544_2135.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0262.
HOGENOM	HOG000040233.
KO	K00287.
OMA	QDEEGVI.
ProtClustDB	CLSK820192.
Enzyme and pathway databases
BioCyc	RPAL316058:GHF1-2097-MONOMER.
UniPathway	UPA00077.
Family and domain databases
Gene3D	3.40.430.10. 1 hit.
InterPro	IPR012259. DHFR. IPR024072. DHFR-like_dom. IPR017925. DHFR_CS. IPR001796. DHFR_dom. [Graphical view]
Pfam	PF00186. DHFR_1. 1 hit. [Graphical view]
PIRSF	PIRSF000194. DHFR. 1 hit.
PRINTS	PR00070. DHFR.
SUPFAM	SSF53597. SSF53597. 1 hit.
PROSITE	PS00075. DHFR_1. 1 hit. PS51330. DHFR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2IYG6_RHOP2

Accession

Primary (citable) accession number: Q2IYG6

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)