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Q2IYG6

- Q2IYG6_RHOP2

UniProt

Q2IYG6 - Q2IYG6_RHOP2

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Protein
Dihydrofolate reductase
Gene
RPB_2037
Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.UniRule annotation

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. dihydrofolate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycine biosynthetic process Source: InterPro
  2. nucleotide biosynthetic process Source: InterPro
  3. one-carbon metabolic process Source: UniProtKB-KW
  4. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

One-carbon metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciRPAL316058:GHF1-2060-MONOMER.
UniPathwayiUPA00077; UER00158.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:RPB_2037Imported
OrganismiRhodopseudomonas palustris (strain HaA2)Imported
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000008809: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_2037.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0262.
HOGENOMiHOG000040233.
KOiK00287.
OMAiFKALTMG.
OrthoDBiEOG6KT2V2.

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000194. DHFR. 1 hit.
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2IYG6-1 [UniParc]FASTAAdd to Basket

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MSSPGVSSRL SIVLIVAVAD NGVIGRDNAI PWRLKSDLQR FKQLTLNKPI    50
IMGRKTYQSI GRPLPGRTNI VVTRDPTFHA DGVVVVPSFD AAEQVACGDA 100
MRRFATEIAV IGGAEIYAHW LPRATRIELT EVHASPPGDA TFPALDPSQW 150
EETARTHHAA GPQDSADVSY VTYRRCTAR 179
Length:179
Mass (Da):19,532
Last modified:March 7, 2006 - v1
Checksum:iDE7E53E1325F87FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD06744.1.
RefSeqiWP_011440932.1. NC_007778.1.
YP_485655.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD06744; ABD06744; RPB_2037.
GeneIDi3909852.
KEGGirpb:RPB_2037.
PATRICi23298683. VBIRhoPal125544_2135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD06744.1 .
RefSeqi WP_011440932.1. NC_007778.1.
YP_485655.1. NC_007778.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316058.RPB_2037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD06744 ; ABD06744 ; RPB_2037 .
GeneIDi 3909852.
KEGGi rpb:RPB_2037.
PATRICi 23298683. VBIRhoPal125544_2135.

Phylogenomic databases

eggNOGi COG0262.
HOGENOMi HOG000040233.
KOi K00287.
OMAi FKALTMG.
OrthoDBi EOG6KT2V2.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00158 .
BioCyci RPAL316058:GHF1-2060-MONOMER.

Family and domain databases

Gene3Di 3.40.430.10. 1 hit.
InterProi IPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view ]
Pfami PF00186. DHFR_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000194. DHFR. 1 hit.
PRINTSi PR00070. DHFR.
SUPFAMi SSF53597. SSF53597. 1 hit.
PROSITEi PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HaA2Imported.

Entry informationi

Entry nameiQ2IYG6_RHOP2
AccessioniPrimary (citable) accession number: Q2IYG6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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