Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pantothenate synthetase

Gene

panC

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Proton donorUniRule annotation1
Binding sitei65Beta-alanineUniRule annotation1
Binding sitei65PantoateUniRule annotation1
Binding sitei158PantoateUniRule annotation1
Binding sitei181ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPUniRule annotation8
Nucleotide bindingi152 – 155ATPUniRule annotation4
Nucleotide bindingi189 – 192ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-2427-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:RPB_2388
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003055361 – 283Pantothenate synthetaseAdd BLAST283

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_2388

Structurei

3D structure databases

ProteinModelPortaliQ2IXG7
SMRiQ2IXG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IAA Bacteria
COG0414 LUCA
HOGENOMiHOG000175516
KOiK01918
OMAiLFNMVQP
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2IXG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPPVVART LPALRRALDD LRRRNATVAL VPTMGALHDG HLSLVRLAKR
60 70 80 90 100
RAAKVVVSVF VNPTQFAPHE DFGSYPRTWK ADVAKLAAEN VDLIWNPDVK
110 120 130 140 150
TMYPEGFATR IGVDGPAIAG LEDRFRPHFF GGVATVVGKL FLQVRPDVAI
160 170 180 190 200
FGSKDFQQLR VVTRMAADLD LGVKVIGAPT IRERDGLAMS SRNVYLTPEQ
210 220 230 240 250
RQVAPTLYRA MKETAKLLKA GRSAEAALAA GAKMITDAGF ALDYLEARHA
260 270 280
ESLAPVGSIK DGPIRLLVAA KLGNTRLIDN VAV
Length:283
Mass (Da):30,720
Last modified:March 7, 2006 - v1
Checksum:iBE150C5D7E935E73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD07093.1
RefSeqiWP_011441278.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD07093; ABD07093; RPB_2388
KEGGirpb:RPB_2388

Similar proteinsi

Entry informationi

Entry nameiPANC_RHOP2
AccessioniPrimary (citable) accession number: Q2IXG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health