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Q2IWR7 (Q2IWR7_RHOP2) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
K(+)-insensitive pyrophosphate-energized proton pump HAMAP-Rule MF_01129
EC=3.6.1.1 HAMAP-Rule MF_01129
Alternative name(s):
Membrane-bound proton-translocating pyrophosphatase HAMAP-Rule MF_01129
Pyrophosphate-energized inorganic pyrophosphatase HAMAP-Rule MF_01129
Pyrophosphate-energized proton pump HAMAP-Rule MF_01129
Gene names
Name:hppA HAMAP-Rule MF_01129
Ordered Locus Names:RPB_2641
OrganismRhodopseudomonas palustris (strain HaA2) [Complete proteome] [HAMAP] EMBL ABD07343.1
Taxonomic identifier316058 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas ›

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force By similarity. HAMAP-Rule MF_01129

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP-Rule MF_01129

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01129

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01129

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01129.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily. [View classification] HAMAP-Rule MF_01129

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential EMBL ABD07343.1
Chain29 – 707679 Potential EMBL ABD07343.1
PRO_5000107393

Regions

Transmembrane1 – 2121Helical; By similarity HAMAP-Rule MF_01129
Transmembrane62 – 8221Helical; By similarity HAMAP-Rule MF_01129
Transmembrane126 – 14621Helical; By similarity HAMAP-Rule MF_01129
Transmembrane164 – 18421Helical; By similarity HAMAP-Rule MF_01129
Transmembrane231 – 25121Helical; By similarity HAMAP-Rule MF_01129
Transmembrane262 – 28221Helical; By similarity HAMAP-Rule MF_01129
Transmembrane299 – 31921Helical; By similarity HAMAP-Rule MF_01129
Transmembrane329 – 34921Helical; By similarity HAMAP-Rule MF_01129
Transmembrane392 – 41221Helical; By similarity HAMAP-Rule MF_01129
Transmembrane413 – 43321Helical; By similarity HAMAP-Rule MF_01129
Transmembrane466 – 48621Helical; By similarity HAMAP-Rule MF_01129
Transmembrane517 – 53721Helical; By similarity HAMAP-Rule MF_01129
Transmembrane586 – 60621Helical; By similarity HAMAP-Rule MF_01129
Transmembrane617 – 63721Helical; By similarity HAMAP-Rule MF_01129

Sites

Site4651Determinant of potassium independence By similarity HAMAP-Rule MF_01129

Sequences

Sequence LengthMass (Da)Tools
Q2IWR7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 4FC5AE83E996CB60

FASTA70772,241
        10         20         30         40         50         60 
MTALWVIVLC GALAIVYAVW ATSSVLAADQ GNARMQEIAA AVREGAQAYL KRQYMTIAIV 

        70         80         90        100        110        120 
GVVIFALLAY FLGVLVAIGF LIGAVLSGAA GFIGMNVSVR ANVRTAQAAT TSLAGGLELA 

       130        140        150        160        170        180 
FKAGAITGLL VAGLALLGVT LYFIYLIHYA NLAPNSRTVV DALVALGFGA SLISIFARLG 

       190        200        210        220        230        240 
GGIFTKGADV GGDLVGKVEA GIPEDDPRNP ATIADNVGDN VGDCAGMAAD LFETYAVTAV 

       250        260        270        280        290        300 
ATMVLAAIFF AATPDLLLNM MTLPLAIGGI CILTSIAGTF FVKLGASQSI MGALYKGLIA 

       310        320        330        340        350        360 
TGVLSLIGVG AVIHQLIGFG PLAGVSYTGL ALFECGIVGL AVTGLIIWIT EYYTGTDYRP 

       370        380        390        400        410        420 
VKSIAQSSVT GHGTNVIQGL AISMESTALP AIVIIAGILV TYSLAGLFGI AIATTTMLAL 

       430        440        450        460        470        480 
AGMIVALDAF GPVTDNAGGI AEMAGLPKEV RKATDALDAV GNTTKAVTKG YAIGSAGLGA 

       490        500        510        520        530        540 
LVLFAAYNED LKFFIANAAK YPYFEGVLPD FSLNNPYVVV GLLFGGLLPY LFGAMGMTAV 

       550        560        570        580        590        600 
GRAAGAIVEE VRRQFREKPG IMKGTDKPDY GKAVDLLTKA AIKEMIIPSL LPVLSPIFVY 

       610        620        630        640        650        660 
FVIYAIAGGG PAGKSAAFSA VGAMLLGVIV TGLFVAISMT SGGGAWDNAK KYIEDGHHGG 

       670        680        690        700 
KGSDAHKAAV TGDTVGDPYK DTAGPAVNPM IKITNIVALL LLAILAH

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References

[1]"Complete sequence of Rhodopseudomonas palustris HaA2."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A. expand/collapse author list , Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HaA2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000250 Genomic DNA. Translation: ABD07343.1.
RefSeqYP_486254.1. NC_007778.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING316058.RPB_2641.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD07343; ABD07343; RPB_2641.
GeneID3910433.
KEGGrpb:RPB_2641.
PATRIC23299997. VBIRhoPal125544_2781.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3808.
HOGENOMHOG000007098.
KOK15987.
OMAQYMTIAI.
ProtClustDBPRK00733.

Enzyme and pathway databases

BioCycRPAL316058:GHF1-2701-MONOMER.

Family and domain databases

HAMAPMF_01129. PPase_energized_pump.
InterProIPR004131. PPase-energised_H-pump.
[Graphical view]
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsTIGR01104. V_PPase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2IWR7_RHOP2
AccessionPrimary (citable) accession number: Q2IWR7
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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