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Protein

K(+)-insensitive pyrophosphate-energized proton pump

Gene

hppA

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei465Determinant of potassium independenceUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport
LigandMagnesiumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
K(+)-insensitive pyrophosphate-energized proton pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Membrane-bound proton-translocating pyrophosphataseUniRule annotation
Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
Short name:
H(+)-PPaseUniRule annotation
Gene namesi
Name:hppAUniRule annotation
Ordered Locus Names:RPB_2641Imported
OrganismiRhodopseudomonas palustris (strain HaA2)Imported
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 28HelicalUniRule annotationAdd BLAST23
Transmembranei54 – 72HelicalUniRule annotationAdd BLAST19
Transmembranei78 – 99HelicalUniRule annotationAdd BLAST22
Transmembranei119 – 147HelicalUniRule annotationAdd BLAST29
Transmembranei159 – 177HelicalUniRule annotationAdd BLAST19
Transmembranei235 – 253HelicalUniRule annotationAdd BLAST19
Transmembranei265 – 286HelicalUniRule annotationAdd BLAST22
Transmembranei298 – 317HelicalUniRule annotationAdd BLAST20
Transmembranei329 – 349HelicalUniRule annotationAdd BLAST21
Transmembranei392 – 425HelicalUniRule annotationAdd BLAST34
Transmembranei517 – 548HelicalUniRule annotationAdd BLAST32
Transmembranei589 – 610HelicalUniRule annotationAdd BLAST22
Transmembranei616 – 637HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_2641.

Family & Domainsi

Sequence similaritiesi

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105EAY. Bacteria.
COG3808. LUCA.
HOGENOMiHOG000007098.
KOiK15987.
OMAiMATTAMQ.
OrthoDBiPOG091H0DQP.

Family and domain databases

HAMAPiMF_01129. PPase_energized_pump. 1 hit.
InterProiView protein in InterPro
IPR004131. PPase-energised_H-pump.
PANTHERiPTHR31998. PTHR31998. 1 hit.
PfamiView protein in Pfam
PF03030. H_PPase. 1 hit.
PIRSFiPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsiTIGR01104. V_PPase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2IWR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALWVIVLC GALAIVYAVW ATSSVLAADQ GNARMQEIAA AVREGAQAYL
60 70 80 90 100
KRQYMTIAIV GVVIFALLAY FLGVLVAIGF LIGAVLSGAA GFIGMNVSVR
110 120 130 140 150
ANVRTAQAAT TSLAGGLELA FKAGAITGLL VAGLALLGVT LYFIYLIHYA
160 170 180 190 200
NLAPNSRTVV DALVALGFGA SLISIFARLG GGIFTKGADV GGDLVGKVEA
210 220 230 240 250
GIPEDDPRNP ATIADNVGDN VGDCAGMAAD LFETYAVTAV ATMVLAAIFF
260 270 280 290 300
AATPDLLLNM MTLPLAIGGI CILTSIAGTF FVKLGASQSI MGALYKGLIA
310 320 330 340 350
TGVLSLIGVG AVIHQLIGFG PLAGVSYTGL ALFECGIVGL AVTGLIIWIT
360 370 380 390 400
EYYTGTDYRP VKSIAQSSVT GHGTNVIQGL AISMESTALP AIVIIAGILV
410 420 430 440 450
TYSLAGLFGI AIATTTMLAL AGMIVALDAF GPVTDNAGGI AEMAGLPKEV
460 470 480 490 500
RKATDALDAV GNTTKAVTKG YAIGSAGLGA LVLFAAYNED LKFFIANAAK
510 520 530 540 550
YPYFEGVLPD FSLNNPYVVV GLLFGGLLPY LFGAMGMTAV GRAAGAIVEE
560 570 580 590 600
VRRQFREKPG IMKGTDKPDY GKAVDLLTKA AIKEMIIPSL LPVLSPIFVY
610 620 630 640 650
FVIYAIAGGG PAGKSAAFSA VGAMLLGVIV TGLFVAISMT SGGGAWDNAK
660 670 680 690 700
KYIEDGHHGG KGSDAHKAAV TGDTVGDPYK DTAGPAVNPM IKITNIVALL

LLAILAH
Length:707
Mass (Da):72,241
Last modified:March 7, 2006 - v1
Checksum:i4FC5AE83E996CB60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA. Translation: ABD07343.1.
RefSeqiWP_011441528.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD07343; ABD07343; RPB_2641.
KEGGirpb:RPB_2641.

Similar proteinsi

Entry informationi

Entry nameiQ2IWR7_RHOP2
AccessioniPrimary (citable) accession number: Q2IWR7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 27, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported