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Protein

K(+)-insensitive pyrophosphate-energized proton pump

Gene

hppA

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei465Determinant of potassium independenceUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

MagnesiumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
K(+)-insensitive pyrophosphate-energized proton pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Membrane-bound proton-translocating pyrophosphataseUniRule annotation
Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
Gene namesi
Name:hppAUniRule annotation
Ordered Locus Names:RPB_2641Imported
OrganismiRhodopseudomonas palustris (strain HaA2)Imported
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei62 – 82HelicalUniRule annotationAdd BLAST21
Transmembranei126 – 146HelicalUniRule annotationAdd BLAST21
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 251HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 282HelicalUniRule annotationAdd BLAST21
Transmembranei299 – 319HelicalUniRule annotationAdd BLAST21
Transmembranei329 – 349HelicalUniRule annotationAdd BLAST21
Transmembranei392 – 412HelicalUniRule annotationAdd BLAST21
Transmembranei413 – 433HelicalUniRule annotationAdd BLAST21
Transmembranei466 – 486HelicalUniRule annotationAdd BLAST21
Transmembranei517 – 537HelicalUniRule annotationAdd BLAST21
Transmembranei586 – 606HelicalUniRule annotationAdd BLAST21
Transmembranei617 – 637HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_2641.

Family & Domainsi

Sequence similaritiesi

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105EAY. Bacteria.
COG3808. LUCA.
HOGENOMiHOG000007098.
KOiK15987.
OMAiNVMPALY.
OrthoDBiPOG091H0DQP.

Family and domain databases

HAMAPiMF_01129. PPase_energized_pump. 1 hit.
InterProiIPR004131. PPase-energised_H-pump.
[Graphical view]
PfamiPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFiPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsiTIGR01104. V_PPase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2IWR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALWVIVLC GALAIVYAVW ATSSVLAADQ GNARMQEIAA AVREGAQAYL
60 70 80 90 100
KRQYMTIAIV GVVIFALLAY FLGVLVAIGF LIGAVLSGAA GFIGMNVSVR
110 120 130 140 150
ANVRTAQAAT TSLAGGLELA FKAGAITGLL VAGLALLGVT LYFIYLIHYA
160 170 180 190 200
NLAPNSRTVV DALVALGFGA SLISIFARLG GGIFTKGADV GGDLVGKVEA
210 220 230 240 250
GIPEDDPRNP ATIADNVGDN VGDCAGMAAD LFETYAVTAV ATMVLAAIFF
260 270 280 290 300
AATPDLLLNM MTLPLAIGGI CILTSIAGTF FVKLGASQSI MGALYKGLIA
310 320 330 340 350
TGVLSLIGVG AVIHQLIGFG PLAGVSYTGL ALFECGIVGL AVTGLIIWIT
360 370 380 390 400
EYYTGTDYRP VKSIAQSSVT GHGTNVIQGL AISMESTALP AIVIIAGILV
410 420 430 440 450
TYSLAGLFGI AIATTTMLAL AGMIVALDAF GPVTDNAGGI AEMAGLPKEV
460 470 480 490 500
RKATDALDAV GNTTKAVTKG YAIGSAGLGA LVLFAAYNED LKFFIANAAK
510 520 530 540 550
YPYFEGVLPD FSLNNPYVVV GLLFGGLLPY LFGAMGMTAV GRAAGAIVEE
560 570 580 590 600
VRRQFREKPG IMKGTDKPDY GKAVDLLTKA AIKEMIIPSL LPVLSPIFVY
610 620 630 640 650
FVIYAIAGGG PAGKSAAFSA VGAMLLGVIV TGLFVAISMT SGGGAWDNAK
660 670 680 690 700
KYIEDGHHGG KGSDAHKAAV TGDTVGDPYK DTAGPAVNPM IKITNIVALL

LLAILAH
Length:707
Mass (Da):72,241
Last modified:March 7, 2006 - v1
Checksum:i4FC5AE83E996CB60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA. Translation: ABD07343.1.
RefSeqiWP_011441528.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD07343; ABD07343; RPB_2641.
KEGGirpb:RPB_2641.
PATRICi23299997. VBIRhoPal125544_2781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA. Translation: ABD07343.1.
RefSeqiWP_011441528.1. NC_007778.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316058.RPB_2641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD07343; ABD07343; RPB_2641.
KEGGirpb:RPB_2641.
PATRICi23299997. VBIRhoPal125544_2781.

Phylogenomic databases

eggNOGiENOG4105EAY. Bacteria.
COG3808. LUCA.
HOGENOMiHOG000007098.
KOiK15987.
OMAiNVMPALY.
OrthoDBiPOG091H0DQP.

Family and domain databases

HAMAPiMF_01129. PPase_energized_pump. 1 hit.
InterProiIPR004131. PPase-energised_H-pump.
[Graphical view]
PfamiPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFiPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsiTIGR01104. V_PPase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ2IWR7_RHOP2
AccessioniPrimary (citable) accession number: Q2IWR7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.