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Q2IWR7

- Q2IWR7_RHOP2

UniProt

Q2IWR7 - Q2IWR7_RHOP2

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Protein

K(+)-insensitive pyrophosphate-energized proton pump

Gene

hppA

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Note: Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei465 – 4651Determinant of potassium independenceUniRule annotation

GO - Molecular functioni

  1. hydrogen-translocating pyrophosphatase activity Source: UniProtKB-HAMAP
  2. inorganic diphosphatase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

MagnesiumUniRule annotation

Enzyme and pathway databases

BioCyciRPAL316058:GHF1-2675-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
K(+)-insensitive pyrophosphate-energized proton pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Membrane-bound proton-translocating pyrophosphataseUniRule annotation
Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
Gene namesi
Name:hppAUniRule annotation
Ordered Locus Names:RPB_2641Imported
OrganismiRhodopseudomonas palustris (strain HaA2)Imported
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000008809: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei62 – 8221HelicalUniRule annotationAdd
BLAST
Transmembranei126 – 14621HelicalUniRule annotationAdd
BLAST
Transmembranei164 – 18421HelicalUniRule annotationAdd
BLAST
Transmembranei231 – 25121HelicalUniRule annotationAdd
BLAST
Transmembranei262 – 28221HelicalUniRule annotationAdd
BLAST
Transmembranei299 – 31921HelicalUniRule annotationAdd
BLAST
Transmembranei329 – 34921HelicalUniRule annotationAdd
BLAST
Transmembranei392 – 41221HelicalUniRule annotationAdd
BLAST
Transmembranei413 – 43321HelicalUniRule annotationAdd
BLAST
Transmembranei466 – 48621HelicalUniRule annotationAdd
BLAST
Transmembranei517 – 53721HelicalUniRule annotationAdd
BLAST
Transmembranei586 – 60621HelicalUniRule annotationAdd
BLAST
Transmembranei617 – 63721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 PotentialImportedAdd
BLAST
Chaini29 – 707679 PotentialImportedPRO_5000107393Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_2641.

Family & Domainsi

Sequence similaritiesi

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily. [View classification]UniRule annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiCOG3808.
HOGENOMiHOG000007098.
KOiK15987.
OMAiLYKGLAV.
OrthoDBiEOG6TXQSF.

Family and domain databases

HAMAPiMF_01129. PPase_energized_pump.
InterProiIPR004131. PPase-energised_H-pump.
[Graphical view]
PfamiPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFiPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsiTIGR01104. V_PPase. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2IWR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTALWVIVLC GALAIVYAVW ATSSVLAADQ GNARMQEIAA AVREGAQAYL
60 70 80 90 100
KRQYMTIAIV GVVIFALLAY FLGVLVAIGF LIGAVLSGAA GFIGMNVSVR
110 120 130 140 150
ANVRTAQAAT TSLAGGLELA FKAGAITGLL VAGLALLGVT LYFIYLIHYA
160 170 180 190 200
NLAPNSRTVV DALVALGFGA SLISIFARLG GGIFTKGADV GGDLVGKVEA
210 220 230 240 250
GIPEDDPRNP ATIADNVGDN VGDCAGMAAD LFETYAVTAV ATMVLAAIFF
260 270 280 290 300
AATPDLLLNM MTLPLAIGGI CILTSIAGTF FVKLGASQSI MGALYKGLIA
310 320 330 340 350
TGVLSLIGVG AVIHQLIGFG PLAGVSYTGL ALFECGIVGL AVTGLIIWIT
360 370 380 390 400
EYYTGTDYRP VKSIAQSSVT GHGTNVIQGL AISMESTALP AIVIIAGILV
410 420 430 440 450
TYSLAGLFGI AIATTTMLAL AGMIVALDAF GPVTDNAGGI AEMAGLPKEV
460 470 480 490 500
RKATDALDAV GNTTKAVTKG YAIGSAGLGA LVLFAAYNED LKFFIANAAK
510 520 530 540 550
YPYFEGVLPD FSLNNPYVVV GLLFGGLLPY LFGAMGMTAV GRAAGAIVEE
560 570 580 590 600
VRRQFREKPG IMKGTDKPDY GKAVDLLTKA AIKEMIIPSL LPVLSPIFVY
610 620 630 640 650
FVIYAIAGGG PAGKSAAFSA VGAMLLGVIV TGLFVAISMT SGGGAWDNAK
660 670 680 690 700
KYIEDGHHGG KGSDAHKAAV TGDTVGDPYK DTAGPAVNPM IKITNIVALL

LLAILAH
Length:707
Mass (Da):72,241
Last modified:March 7, 2006 - v1
Checksum:i4FC5AE83E996CB60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA. Translation: ABD07343.1.
RefSeqiWP_011441528.1. NC_007778.1.
YP_486254.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD07343; ABD07343; RPB_2641.
GeneIDi3910433.
KEGGirpb:RPB_2641.
PATRICi23299997. VBIRhoPal125544_2781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA. Translation: ABD07343.1 .
RefSeqi WP_011441528.1. NC_007778.1.
YP_486254.1. NC_007778.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316058.RPB_2641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD07343 ; ABD07343 ; RPB_2641 .
GeneIDi 3910433.
KEGGi rpb:RPB_2641.
PATRICi 23299997. VBIRhoPal125544_2781.

Phylogenomic databases

eggNOGi COG3808.
HOGENOMi HOG000007098.
KOi K15987.
OMAi LYKGLAV.
OrthoDBi EOG6TXQSF.

Enzyme and pathway databases

BioCyci RPAL316058:GHF1-2675-MONOMER.

Family and domain databases

HAMAPi MF_01129. PPase_energized_pump.
InterProi IPR004131. PPase-energised_H-pump.
[Graphical view ]
Pfami PF03030. H_PPase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001265. H+-PPase. 1 hit.
TIGRFAMsi TIGR01104. V_PPase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HaA2Imported.

Entry informationi

Entry nameiQ2IWR7_RHOP2
AccessioniPrimary (citable) accession number: Q2IWR7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3