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Protein

Protein-L-isoaspartate O-methyltransferase 2

Gene

pcm2

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-2781-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase 2UniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase 2UniRule annotation
Protein L-isoaspartyl methyltransferase 2UniRule annotation
Protein-beta-aspartate methyltransferase 2UniRule annotation
Short name:
PIMT 2UniRule annotation
Gene namesi
Name:pcm2UniRule annotation
Ordered Locus Names:RPB_2737
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003519271 – 217Protein-L-isoaspartate O-methyltransferase 2Add BLAST217

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_2737

Structurei

3D structure databases

ProteinModelPortaliQ2IWH1
SMRiQ2IWH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26 Bacteria
COG2518 LUCA
HOGENOMiHOG000257189
KOiK00573
OMAiYSSRTIP
OrthoDBiPOG091H06AY

Family and domain databases

HAMAPiMF_00090 PIMT, 1 hit
InterProiView protein in InterPro
IPR000682 PCMT
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11579 PTHR11579, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00080 pimt, 1 hit

Sequencei

Sequence statusi: Complete.

Q2IWH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSVAPPPE KMLFQLSLRR RGISDRGVLQ AMESVPRDRF VDAVHRDSAW
60 70 80 90 100
RDTALPIACG QTISQPFVVA YMTEQLHLQP GHRVLEIGTG SGYHAAVLSR
110 120 130 140 150
LVRDVVSVER FKTLADRARA RLKELNYANV EVVLGDGFAL PEGQGTFDRI
160 170 180 190 200
LVTAAMAELP QPLLDLLDPD GILIAPIGPG NGRQTLIRVQ RKDDGFLRKP
210
LVDVRFVPAL PGIAREL
Length:217
Mass (Da):23,904
Last modified:March 7, 2006 - v1
Checksum:i2455AE1487410539
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD07439.1
RefSeqiWP_011441624.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD07439; ABD07439; RPB_2737
KEGGirpb:RPB_2737

Similar proteinsi

Entry informationi

Entry nameiPIMT2_RHOP2
AccessioniPrimary (citable) accession number: Q2IWH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health