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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei81Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei89PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi93Magnesium 1UniRule annotation1
Binding sitei112Anthranilate 1UniRule annotation1
Binding sitei121Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei167Anthranilate 2UniRule annotation1
Metal bindingi226Magnesium 2UniRule annotation1
Metal bindingi227Magnesium 1UniRule annotation1
Metal bindingi227Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:RPB_2797
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003254561 – 338Anthranilate phosphoribosyltransferaseAdd BLAST338

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_2797.

Structurei

3D structure databases

ProteinModelPortaliQ2IWB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni91 – 94Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni109 – 117Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OrthoDBiPOG091H01QX.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2IWB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDFKAVIAK VATGASLTRD EAANAFDAMM SGDATPSQMG ALLMGLRVRG
60 70 80 90 100
ETVDEITGAV TTMRAKMLTV AAPPDAVDVV GTGGDGSGSV NVSTCTSFVV
110 120 130 140 150
AGCGVPVAKH GNRALSSKSG AADVLNALGV KIDITPDHVG RCVAEAGIGF
160 170 180 190 200
MFAPTHHPAM KNVGPTRVEL ATRTIFNLLG PLSNPAGVKR QMIGVFSRQW
210 220 230 240 250
VQPLAQVLQN LGSESIWVVH GSDGLDEITL SGPTAVAELK NGEIRTFEIG
260 270 280 290 300
PEDAGLPRAP ADALKGGDAE ANAVALRAVL EGMPGPYRDV ALLNAAATLI
310 320 330
VAGKAKDLKE GVALGAQSID SGAAEARLKK LIAVSAAA
Length:338
Mass (Da):34,393
Last modified:March 18, 2008 - v2
Checksum:iBBA242AD86E5D0CF
GO

Sequence cautioni

The sequence ABD07499 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA. Translation: ABD07499.1. Different initiation.
RefSeqiWP_041798729.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD07499; ABD07499; RPB_2797.
KEGGirpb:RPB_2797.
PATRICi23300331. VBIRhoPal125544_2947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA. Translation: ABD07499.1. Different initiation.
RefSeqiWP_041798729.1. NC_007778.1.

3D structure databases

ProteinModelPortaliQ2IWB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316058.RPB_2797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD07499; ABD07499; RPB_2797.
KEGGirpb:RPB_2797.
PATRICi23300331. VBIRhoPal125544_2947.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OrthoDBiPOG091H01QX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_RHOP2
AccessioniPrimary (citable) accession number: Q2IWB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.