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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (RPB_2817)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-2860-MONOMER
UniPathwayiUPA00359; UER00481

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:RPB_2815
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002552161 – 393Lipid-A-disaccharide synthaseAdd BLAST393

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_2815

Structurei

3D structure databases

ProteinModelPortaliQ2IW93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018004
KOiK00748
OMAiPTVWAWR
OrthoDBiPOG091H01NW

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

Q2IW93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAANATTGA VRRLFLIATE ESGDRLGAAL MQALKTRLGD GVVFEGVGGR
60 70 80 90 100
AMAEQGLVSL FPIEELSIMG ISAVVRRLPS ILRRIRSTAD AVLGAKPDML
110 120 130 140 150
IIIDSPDFTH RVARRVRVRD PSIAIVNYVS PTVWAWRPGR ARAMRRYVDH
160 170 180 190 200
VLALLPFEPE EYRRLRGPPC TYVGHPLTEQ IAHLRPSPAE QARRDAEPPV
210 220 230 240 250
LVVLPGSRRS EIHHLMAVFG ETLGRLQAEQ GDLELILPTV PHLRDAVEAG
260 270 280 290 300
VRDWPVQPRI VVGDADKKAA FRIARAAFAK SGTVTLELAL AHVPMVAVYK
310 320 330 340 350
AGAMEAWIGK RVIRSASVIL ANLVVGENVI PEFIQEDCVP DRLVPALREV
360 370 380 390
LADTPMRARQ LEGFGRIDDI MSTGAQTPSG RAADIVLNVL RKH
Length:393
Mass (Da):43,078
Last modified:March 7, 2006 - v1
Checksum:i88C53894FD534D7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD07517.1
RefSeqiWP_011441702.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD07517; ABD07517; RPB_2815
KEGGirpb:RPB_2815

Similar proteinsi

Entry informationi

Entry nameiLPXB_RHOP2
AccessioniPrimary (citable) accession number: Q2IW93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health