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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124Substrate; in homodimeric partnerUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1
Binding sitei178SubstrateUniRule annotation1
Metal bindingi202Magnesium; via carbamate groupUniRule annotation1
Metal bindingi204MagnesiumUniRule annotation1
Metal bindingi205MagnesiumUniRule annotation1
Active sitei294Proton acceptorUniRule annotation1
Binding sitei295SubstrateUniRule annotation1
Binding sitei327SubstrateUniRule annotation1
Sitei334Transition state stabilizerUniRule annotation1
Binding sitei379SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processCalvin cycle, Carbon dioxide fixation, Photosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-4029-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Ordered Locus Names:RPB_3964
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514561 – 485Ribulose bisphosphate carboxylase large chainAdd BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_3964

Structurei

3D structure databases

ProteinModelPortaliQ2IT03
SMRiQ2IT03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DT1 Bacteria
COG1850 LUCA
HOGENOMiHOG000230831
KOiK01601
OMAiHRAMHAA
OrthoDBiPOG091H14UZ

Family and domain databases

CDDicd08212 RuBisCO_large_I, 1 hit
Gene3Di3.20.20.110, 1 hit
3.30.70.150, 1 hit
HAMAPiMF_01338 RuBisCO_L_type1, 1 hit
InterProiView protein in InterPro
IPR033966 RuBisCO
IPR020878 RuBisCo_large_chain_AS
IPR000685 RuBisCO_lsu_C
IPR036376 RuBisCO_lsu_C_sf
IPR017443 RuBisCO_lsu_fd_N
IPR036422 RuBisCO_lsu_N_sf
IPR020888 RuBisCO_lsuI
PfamiView protein in Pfam
PF00016 RuBisCO_large, 1 hit
PF02788 RuBisCO_large_N, 1 hit
SFLDiSFLDS00014 RuBisCO, 1 hit
SUPFAMiSSF51649 SSF51649, 1 hit
SSF54966 SSF54966, 1 hit
PROSITEiView protein in PROSITE
PS00157 RUBISCO_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q2IT03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESVTVRGK DRYKSGVMEY KKMGYWEPDY EPKDTDVIAL FRVTPQDGVD
60 70 80 90 100
PIEASAAVAG ESSTATWTVV WTDRLTAAEK YRAKCYRVDP VPNSPGQYFA
110 120 130 140 150
YIAYDLDLFE NGSIANLSAS IIGNVFGFKP LKALRLEDMR LPVAYVKTFQ
160 170 180 190 200
GPATGIVVER ERMDKFGRPL LGATVKPKLG LSGRNYGRVV YEALKGGLDF
210 220 230 240 250
TKDDENINSQ PFMHWRERFL YCMEAVNKAQ AASGEIKGTY LNVTAGTMEE
260 270 280 290 300
MYERAEFAKQ LGSVIIMIDL VIGYTAIQSM AKWARKNDMI LHLHRAGHST
310 320 330 340 350
YTRQRNHGVS FRVIAKWMRL AGVDHIHAGT VVGKLEGDPA TTKGYYDICR
360 370 380 390 400
EDYNPANLEH GLFFDQHWAS LNKLMPVASG GIHAGQMHQL LDLLGEDVVL
410 420 430 440 450
QFGGGTIGHP MGIAAGATAN RVALEAMILA RNEGRDYVHE GPEILAKAAQ
460 470 480
TCTPLKAALD TWKNVSFNYE STDTPDYAPT PSVSV
Length:485
Mass (Da):53,713
Last modified:March 7, 2006 - v1
Checksum:i91F337AC15FFF53A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD08657.1
RefSeqiWP_011442841.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD08657; ABD08657; RPB_3964
KEGGirpb:RPB_3964

Similar proteinsi

Entry informationi

Entry nameiRBL_RHOP2
AccessioniPrimary (citable) accession number: Q2IT03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health