Reviewed, UniProtKB/Swiss-Prot Q2IQE7 (PUR5_ANADE)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	Adeh_1255

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/5. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_0000258326

Sequences

	Sequence		Length	Mass (Da)
	Q2IQE7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: B436F7CF742A231C	FASTA	345	36,501
	10 20 30 40 50 60 MSLTYRDAGV DIDEGDRLVD LIKPHARPTL RPEVLGGIGG FGGLFALDVK KYREPVLVSG 70 80 90 100 110 120 TDGVGTKLKV AFAADRHDTV GIDLVAMCVN DIAVVGAEPL FFLDYYATGK LSAEQGAEVV 130 140 150 160 170 180 KGIAEGCRQA GCALIGGETA ELPGFYARGE YDLAGFAVGC VDRPRIVDGT RVARGDVVIG 190 200 210 220 230 240 IASSGLHSNG FSLARKALLD RYPLDHRFEG LGGRTLADAL LEPTRIYAKD VLALLDQVPV 250 260 270 280 290 300 RAFAHITGGG LPGNVPRTLP DGTRAVLEEK RWPRPAIFDV VEREGQVPRD EMYRTFNMGL 310 320 330 340 GLVAVVAPGD EAAAHAALRA RGLEAWTVGA IEAGGPGEAT CEVVR

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC81029.1.
RefSeq	YP_464466.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3888824.
GenomeReviews	Gene locus Adeh_1255 in contig CP000251_GR.
KEGG	ade:Adeh_1255.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IQE7.
OMA	Q2IQE7. CGKLDPE.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_1255-MON.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ANADE

Accession

Primary (citable) accession number: Q2IQE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)