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Q2IQD6

- GCSPA_ANADE

UniProt

Q2IQD6 - GCSPA_ANADE

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciADEH290397:GI2Z-1259-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Adeh_1243
    OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
    Taxonomic identifieri290397 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000001935: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045635Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi290397.Adeh_1243.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2IQD6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiLPMHASE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2IQD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYHPHTPDD VRAMLDVVGA ERVDDLFRSI PQALRLDRPL DLPPAADEIA    50
    LFSELRRLAA RNETAHPPFV GAGCYPHHVP PVVDQLLLRG EFFTAYTPYQ 100
    PEISQGTLQA LFEWQTFVCL LTGMDVSNAS MYDGATATAE AALMAGRITG 150
    RDKVVVSAAL HPEYRKVLAT YLRSTGDEIV TVPFGADGRT DLAALQQAVD 200
    GRTACVILGY PNFLGVVDAL PEAAAIARKA GALTVSATAE AVSLGLLQAP 250
    GALGADVAVG TFQSFGNPMS FGGPAPGFFA TREKHVRQMP GRVAGATVDK 300
    QGRRGFVLTL STREQHIRRE KATSNICTNS GLCALASTVH LSLLGKRGLA 350
    ELARLNHGRA RMLRDAMERA GCRPVFSGPF FNEQVFDVGD AEAVVAKLAK 400
    RGIVAGAPLA RWFPDAPSAK GALLCAATEL HGPELIQLFA GAVRS 445
    Length:445
    Mass (Da):47,431
    Last modified:March 7, 2006 - v1
    Checksum:iDCA9DE4E6FB9FC7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000251 Genomic DNA. Translation: ABC81017.1.
    RefSeqiWP_011420300.1. NC_007760.1.
    YP_464454.1. NC_007760.1.

    Genome annotation databases

    EnsemblBacteriaiABC81017; ABC81017; Adeh_1243.
    GeneIDi3888812.
    KEGGiade:Adeh_1243.
    PATRICi20918591. VBIAnaDeh31384_1286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000251 Genomic DNA. Translation: ABC81017.1 .
    RefSeqi WP_011420300.1. NC_007760.1.
    YP_464454.1. NC_007760.1.

    3D structure databases

    ProteinModelPortali Q2IQD6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290397.Adeh_1243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC81017 ; ABC81017 ; Adeh_1243 .
    GeneIDi 3888812.
    KEGGi ade:Adeh_1243.
    PATRICi 20918591. VBIAnaDeh31384_1286.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi LPMHASE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci ADEH290397:GI2Z-1259-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2CP-C.

    Entry informationi

    Entry nameiGCSPA_ANADE
    AccessioniPrimary (citable) accession number: Q2IQD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3