Reviewed, UniProtKB/Swiss-Prot Q2IQD6 (GCSPA_ANADE)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	Adeh_1243

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045635

Sequences

	Sequence		Length	Mass (Da)
	Q2IQD6-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: DCA9DE4E6FB9FC7B	FASTA	445	47,431
	10 20 30 40 50 60 MRYHPHTPDD VRAMLDVVGA ERVDDLFRSI PQALRLDRPL DLPPAADEIA LFSELRRLAA 70 80 90 100 110 120 RNETAHPPFV GAGCYPHHVP PVVDQLLLRG EFFTAYTPYQ PEISQGTLQA LFEWQTFVCL 130 140 150 160 170 180 LTGMDVSNAS MYDGATATAE AALMAGRITG RDKVVVSAAL HPEYRKVLAT YLRSTGDEIV 190 200 210 220 230 240 TVPFGADGRT DLAALQQAVD GRTACVILGY PNFLGVVDAL PEAAAIARKA GALTVSATAE 250 260 270 280 290 300 AVSLGLLQAP GALGADVAVG TFQSFGNPMS FGGPAPGFFA TREKHVRQMP GRVAGATVDK 310 320 330 340 350 360 QGRRGFVLTL STREQHIRRE KATSNICTNS GLCALASTVH LSLLGKRGLA ELARLNHGRA 370 380 390 400 410 420 RMLRDAMERA GCRPVFSGPF FNEQVFDVGD AEAVVAKLAK RGIVAGAPLA RWFPDAPSAK 430 440 GALLCAATEL HGPELIQLFA GAVRS

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC81017.1.
RefSeq	YP_464454.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3888812.
GenomeReviews	Gene locus Adeh_1243 in contig CP000251_GR.
KEGG	ade:Adeh_1243.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IQD6.
OMA	Q2IQD6. VANASMY.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_1243-MON.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_ANADE

Accession

Primary (citable) accession number: Q2IQD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)