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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-1259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Adeh_1243
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
Taxonomic identifieri290397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001935 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045635Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi290397.Adeh_1243.

Structurei

3D structure databases

ProteinModelPortaliQ2IQD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiSMYDGST.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2IQD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYHPHTPDD VRAMLDVVGA ERVDDLFRSI PQALRLDRPL DLPPAADEIA
60 70 80 90 100
LFSELRRLAA RNETAHPPFV GAGCYPHHVP PVVDQLLLRG EFFTAYTPYQ
110 120 130 140 150
PEISQGTLQA LFEWQTFVCL LTGMDVSNAS MYDGATATAE AALMAGRITG
160 170 180 190 200
RDKVVVSAAL HPEYRKVLAT YLRSTGDEIV TVPFGADGRT DLAALQQAVD
210 220 230 240 250
GRTACVILGY PNFLGVVDAL PEAAAIARKA GALTVSATAE AVSLGLLQAP
260 270 280 290 300
GALGADVAVG TFQSFGNPMS FGGPAPGFFA TREKHVRQMP GRVAGATVDK
310 320 330 340 350
QGRRGFVLTL STREQHIRRE KATSNICTNS GLCALASTVH LSLLGKRGLA
360 370 380 390 400
ELARLNHGRA RMLRDAMERA GCRPVFSGPF FNEQVFDVGD AEAVVAKLAK
410 420 430 440
RGIVAGAPLA RWFPDAPSAK GALLCAATEL HGPELIQLFA GAVRS
Length:445
Mass (Da):47,431
Last modified:March 7, 2006 - v1
Checksum:iDCA9DE4E6FB9FC7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC81017.1.
RefSeqiWP_011420300.1. NC_007760.1.
YP_464454.1. NC_007760.1.

Genome annotation databases

EnsemblBacteriaiABC81017; ABC81017; Adeh_1243.
KEGGiade:Adeh_1243.
PATRICi20918591. VBIAnaDeh31384_1286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC81017.1.
RefSeqiWP_011420300.1. NC_007760.1.
YP_464454.1. NC_007760.1.

3D structure databases

ProteinModelPortaliQ2IQD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290397.Adeh_1243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC81017; ABC81017; Adeh_1243.
KEGGiade:Adeh_1243.
PATRICi20918591. VBIAnaDeh31384_1286.

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiSMYDGST.
OrthoDBiEOG6XWV3B.

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-1259-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-C.

Entry informationi

Entry nameiGCSPA_ANADE
AccessioniPrimary (citable) accession number: Q2IQD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: April 1, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.