Q2IPZ2 (DXS_ANADE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	Adeh_1097

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 636	636	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256370

Sequences

	Sequence		Length	Mass (Da)
	Q2IPZ2 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 25E8CD0A45444B43	FASTA	636	67,628
	10 20 30 40 50 60 MGRLLDTIDS PADLKKVPVE QLPALCQEIR ELIIQTCARN GGHLGSSLGA VEINVALHHV 70 80 90 100 110 120 FASPQDKLVW DVGHQAYAHK LLTGRRDAFR TIRTEGGLAG FPERHESAHD AFGVGHASTA 130 140 150 160 170 180 ISAALGMIEA KRVTGEPGKV VAVVGDGAMT GGVAFEGLNQ AGYLGRNLLV VLNDNEMSIS 190 200 210 220 230 240 PNVGALSEWF SKKFASRTYN RWRRQVKEFL ESVPKGPEAI GIIRHGINAT KALVTPGILF 250 260 270 280 290 300 EGLGFHYVGP VDGHDVKGLV ETFQKLAVFD GPVLLHAITT KGKGYHPAES DKATRGHGLS 310 320 330 340 350 360 FFDVATGKPV KKSPGAKAYT DLFAEALCEE MEHDPRVVAI TAAMLEGTGL IKAKQRFPDR 370 380 390 400 410 420 TYDVGIAEQH AVTFAAGLAC EGIRPVVAIY STFLQRAYDQ IIHDVALQKL PVTFALDRGG 430 440 450 460 470 480 LVGADGKTHQ GAFDLAYLRC VPGLVLMAPS DENELRHMLH TSLQHDGPAA LRYPRGAGEG 490 500 510 520 530 540 VPLEPARVLE IGKGRLVRNV PGKPDVCVVA AGTTLKAALA AAEALAAEGV AVTVVDPRFV 550 560 570 580 590 600 KPLDEALICA EAARAKRVVT VEEGCLAGGF GTACLEAFER HGLLEAGLGV RRLGIPDEFI 610 620 630 THAEQAKQRA WVGIDAEAIA AACRALVGDR KARGVA

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2CP-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000251 Genomic DNA. Translation: ABC80872.1.
RefSeq	YP_464309.1. NC_007760.1.
3D structure databases
ProteinModelPortal	Q2IPZ2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IPZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3888633.
GenomeReviews	Gene locus Adeh_1097 in contig CP000251_GR.
KEGG	ade:Adeh_1097.
PATRIC	20918279. VBIAnaDeh31384_1137.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	DPILYHG.
PhylomeDB	Q2IPZ2.
ProtClustDB	CLSK2465121.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_1097-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_ANADE

Accession

Primary (citable) accession number: Q2IPZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program