ID   Q2IP24_ANADE            Unreviewed;       939 AA.
AC   Q2IP24;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   OrderedLocusNames=Adeh_0781 {ECO:0000313|EMBL:ABC80556.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC   Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC80556.1, ECO:0000313|Proteomes:UP000001935};
RN   [1] {ECO:0000313|EMBL:ABC80556.1, ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|EMBL:ABC80556.1,
RC   ECO:0000313|Proteomes:UP000001935};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA   Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA   Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|Proteomes:UP000001935};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA   Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA   Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP000251; ABC80556.1; -; Genomic_DNA.
DR   RefSeq; WP_011419839.1; NC_007760.1.
DR   AlphaFoldDB; Q2IP24; -.
DR   STRING; 290397.Adeh_0781; -.
DR   KEGG; ade:Adeh_0781; -.
DR   eggNOG; COG0567; Bacteria.
DR   HOGENOM; CLU_004709_1_0_7; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ABC80556.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001935};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          584..777
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
FT   REGION          47..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          890..909
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   939 AA;  103091 MW;  22045495532E3F27 CRC64;
     MSSPPEPQAL PSAPSLSFVE DLYYAWLADP RSVDESWRRY FEGLPAAPGA APAPASFPRR
     RPDGAAGPQA APGAGGDAAF QSKVDRLVQA YREYGHLRAN LDPLGLVRPA EPFALEAFGL
     GPADLDRPCA DADGRGDRTL RDLVARLEET YCRTLGVELA HMHDQDLRGW LEQRMERTRN
     RLSLAPDVKK LLLRKIVEAE SLEQFLGTKF LGAKRFSVEG AEGFVALLEF LVDRAVGHGV
     RNVVIGMAHR GRLNVLANVV GKPLRQIFAE FRDNAIVNAT GGDVKYHLGH STDRETPDGV
     LVHLSLAFNP SHLEWINTVV QGRVRAKQDR YHDFDRVRSL PVLVHGDASF AGQGIVAEAL
     NMSQLEAYGV GGTIHVIVNN QVGFTTSPRD ARSTTYCTGP ARMLQIPIIH VNGEDLEAVA
     QAVLLAADFR QRFHRDVVID LWAYRRHGHN EGDEPSFTQP VMYRAISKRP TLRQLYAEAL
     EREGTATRAE VDAMAAEYRA RLDEAYQASA QIAVQPGAQE AAGFWAGVKG GAITGPEPET
     GVAPAVLAQA AAGITQVPQG FHVHPKLAKV LEARAEMGRG ERPLDWATAE ALAFATLSLE
     GRRVRLVGQD SRRGTFSHRH AVLYDHQTGT PYSPLAHLRE GQGVVEIRDS LLSEAAALGY
     EYGYSLEMPD ALTLWEAQFG DFVNAAQVII DQFLSSGEAK WNRLSGLALL LPHGMEGQGP
     EHSSARLERF LELSVDDNWY VVNVTTPAQY FHALRRQVYS PWRKPLVVMS PKSLLRHPKA
     VSPIGELAEA RFRPVVADPV ADPSEITRVV LCSGKLYYDL AAAREAQGAR HVALVRLEQL
     YPLAADEILD AIAAFRPGTE MVWAQEEPSN MGAWDYVDLH LSPRLPSRLD LVSRPPSASP
     ASGSATRHKL EQQQLVLEAL GDPVPRIHRT DTRAAAHEH
//