Q2IMQ8 (AHPD_ANADE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	Adeh_0314

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_0000359468
Sites
	Active site	132	1	Proton donor By similarity
	Active site	135	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	132 ↔ 135		Alternate By similarity
	Disulfide bond	135		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2IMQ8 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 0EBC8D63687D7E05	FASTA	186	19,330
	10 20 30 40 50 60 MAALDAIREA LPEPARDIKL NLQAVLQPGP LTPAQRWGVA VATAAAARNE RLLAAILADA 70 80 90 100 110 120 RAEVEPAVVE DALAAAAVMA MNNVYYRFRH MVGKPSYSEK PARLRMNRLV KPAASKLDFE 130 140 150 160 170 180 LFALAVSAVN GCETCVRSHE QVVVGGGVSE DQVHDAVRIA AVVHAAAVAL ELAGHAAAPS AAAAAG

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2CP-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000251 Genomic DNA. Translation: ABC80090.1.
RefSeq	YP_463527.1. NC_007760.1.
3D structure databases
ProteinModelPortal	Q2IMQ8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IMQ8.
Protein family/group databases
PeroxiBase	4611. AdAhpD.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3886550.
GenomeReviews	Gene locus Adeh_0314 in contig CP000251_GR.
KEGG	ade:Adeh_0314.
PATRIC	20916655. VBIAnaDeh31384_0332.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2128.
HOGENOM	HBG414634.
OMA	RAGLRMN.
ProtClustDB	CLSK944971.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_0314-MONOMER.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_ANADE

Accession

Primary (citable) accession number: Q2IMQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program