Reviewed, UniProtKB/Swiss-Prot Q2IMD4 (AROC_ANADE)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Adeh_0186

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Chorismate synthase HAMAP MF_00300		PRO_1000071965

Sequences

	Sequence		Length	Mass (Da)
	Q2IMD4-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 7D7718C9F77BC9A2	FASTA	381	40,537
	10 20 30 40 50 60 MTLRYLTAGE SHGPALVAIA EGFPAGLPVD FEAVDRDLRR RQKGYGRGGR MKIETDAAQF 70 80 90 100 110 120 LAGLRGGVTT GAPIALAVWN KDHENWKDLV SPYARGGRKF TQVRPGHADL AGALKYGLDD 130 140 150 160 170 180 ARDVLERASA RSTAVIVALG ALAKALLSSQ GVEVCSRVVA IGPRDIRPDA PPTPAQRDAI 190 200 210 220 230 240 EASDLHVDDE ALAAEWRALI DAEKARGGSI GGAFDVYATG LPIGLGSHVH PDRRLDARLA 250 260 270 280 290 300 GALCGVQAIR AVEIGDGTQV GRPGYEFHDA IHHDPARGFW RETNRAGGLE GGMTDGMPLR 310 320 330 340 350 360 VRAYMKPIPT MLHPLATVDL ATRAATQARY ERSDVCAVPA AAVVGEAVVA WELANALLEK 370 380 FGGDTVEDVR RAVEAYAARI R

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC79963.1.
RefSeq	YP_463400.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IMD4.
Genome annotation databases
GeneID	3886052.
GenomeReviews	Gene locus Adeh_0186 in contig CP000251_GR.
KEGG	ade:Adeh_0186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IMD4.
OMA	IIEIFIT.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_0186-MON.
Family and domain databases
HAMAP	MF_00300. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
ProDom	PD002941. Chorismate_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. False negative. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ANADE

Accession

Primary (citable) accession number: Q2IMD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 7, 2006
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)