ID   AROE_ANADE              Reviewed;         278 AA.
AC   Q2IMC7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=Adeh_0185;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000251; ABC79962.1; -; Genomic_DNA.
DR   RefSeq; YP_463399.1; -.
DR   GeneID; 3886051; -.
DR   GenomeReviews; CP000251_GR; Adeh_0185.
DR   KEGG; ade:Adeh_0185; -.
DR   HOGENOM; Q2IMC7; -.
DR   OMA; Q2IMC7; ALAFTIW.
DR   BioCyc; ADEH290397:ADEH_0185-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    278       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000325098.
FT   NP_BIND     129    133       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
SQ   SEQUENCE   278 AA;  28771 MW;  296E78778629592F CRC64;
     MITGRTALYG VVGHPVAHSR SPEMQNAAFA KLGVDAAYVA LPVAPERIDE ALRGAHALGF
     QGLNVTVPHK PRAASLCHAL DPVATAVGAA NTLRRTRDGW EGFNTDAPAC RTLLEAAGVA
     RGARALLVGA GGAARAAAWA LLQLGTELRV AARREEAAAE LCRDLAAAVP GADAATADFE
     DLEAEADAAA VVVNGTSVEL PGHEGRLPPL RFRADQVVLD FVYGDTELAR AARAGGARLV
     TGEQVLVRQG ALAFTIWTGL PAPEADMARA LEAREGAR
//