Reviewed, UniProtKB/Swiss-Prot Q2IMC7 (AROE_ANADE)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Adeh_0185

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325098
Regions
	Nucleotide binding	129 – 133	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2IMC7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 296E78778629592F	FASTA	278	28,771
	10 20 30 40 50 60 MITGRTALYG VVGHPVAHSR SPEMQNAAFA KLGVDAAYVA LPVAPERIDE ALRGAHALGF 70 80 90 100 110 120 QGLNVTVPHK PRAASLCHAL DPVATAVGAA NTLRRTRDGW EGFNTDAPAC RTLLEAAGVA 130 140 150 160 170 180 RGARALLVGA GGAARAAAWA LLQLGTELRV AARREEAAAE LCRDLAAAVP GADAATADFE 190 200 210 220 230 240 DLEAEADAAA VVVNGTSVEL PGHEGRLPPL RFRADQVVLD FVYGDTELAR AARAGGARLV 250 260 270 TGEQVLVRQG ALAFTIWTGL PAPEADMARA LEAREGAR

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000251 Genomic DNA. Translation: ABC79962.1.
RefSeq	YP_463399.1.
3D structure databases
HSSP	HSSP built from PDB template 2GPT based on UniProtKB Q9SQT8.
SMR	Q2IMC7. Positions 8-276.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IMC7.
Genome annotation databases
GeneID	3886051.
GenomeReviews	Gene locus Adeh_0185 in contig CP000251_GR.
KEGG	ade:Adeh_0185.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	ALAFTIW.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_0185-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROE_ANADE

Accession

Primary (citable) accession number: Q2IMC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 7, 2006
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)