Reviewed, UniProtKB/Swiss-Prot Q2IMB4 (ARGB_ANADE)

Names and origin

Protein names

Recommended name:
    Acetylglutamate kinase
    EC=2.7.2.8
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate 5-phosphotransferase

Gene names

Name:	argB
Ordered Locus Names:	Adeh_0172

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Acetylglutamate kinase HAMAP MF_00082		PRO_1000092846
Regions
	Region	41 – 42	2	Substrate binding By similarity
Sites
	Binding site	63	1	Substrate By similarity
	Binding site	166	1	Substrate By similarity
	Site	7	1	Transition state stabilizer By similarity
	Site	229	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2IMB4-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 24CF70FA79E5D945	FASTA	270	28,343
	10 20 30 40 50 60 MKTIVLKLGG EIVHSPELDL VARDLRTLVD GWNRVAIVHG GGPQATALQK RLGLETRMVA 70 80 90 100 110 120 GRRYTDEATL EVMKYVVAGQ LNVDLCARLL ANGVMPVGLH GASGHAVQAT RRPPRVMQGA 130 140 150 160 170 180 GPEPVDLGLV GDVVGFNLPL LGDLFERRYV PVLACLGCDD AGQALNINGD TVASQLAGAL 190 200 210 220 230 240 RADALVLVTS TPGVLRDVKD PSSRIPRITR AEFERLVADG TISGGMIPKL EESFEVLRGG 250 260 270 ARSVVILGKL SPGDLVAAVL EPGSAGTVLE

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC79949.1.
RefSeq	YP_463386.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IMB4.
Genome annotation databases
GeneID	3886038.
GenomeReviews	Gene locus Adeh_0172 in contig CP000251_GR.
KEGG	ade:Adeh_0172.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IMB4.
OMA	FVIKYGG.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_0172-MON.
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ANADE

Accession

Primary (citable) accession number: Q2IMB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	March 7, 2006
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)