ID   BIOD_ANADE              Reviewed;         223 AA.
AC   Q2IM14;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Dethiobiotin synthetase;
DE            EC=6.3.3.3;
DE   AltName: Full=Dethiobiotin synthase;
DE   AltName: Full=DTB synthetase;
DE            Short=DTBS;
GN   Name=bioD; OrderedLocusNames=Adeh_0070;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + 7,8-diaminononanoate + CO(2) = ADP +
CC       phosphate + dethiobiotin.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from
CC       6-carboxyhexanoyl-CoA: step 3/4.
CC   -!- SIMILARITY: Belongs to the dethiobiotin synthetase family.
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DR   EMBL; CP000251; ABC79848.1; -; Genomic_DNA.
DR   RefSeq; YP_463285.1; -.
DR   GeneID; 3886230; -.
DR   GenomeReviews; CP000251_GR; Adeh_0070.
DR   KEGG; ade:Adeh_0070; -.
DR   HOGENOM; Q2IM14; -.
DR   OMA; Q2IM14; PAGIVFV.
DR   BioCyc; ADEH290397:ADEH_0070-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004141; F:dethiobiotin synthase activity; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00336; -; 1.
DR   InterPro; IPR004472; BioD_synth.
DR   PIRSF; PIRSF006755; DTB_synth; 1.
DR   TIGRFAMs; TIGR00347; bioD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    223       Dethiobiotin synthetase.
FT                                /FTId=PRO_0000302473.
FT   NP_BIND       8     16       ATP (By similarity).
SQ   SEQUENCE   223 AA;  22788 MW;  19276B658DB1EE8C CRC64;
     MRGLFVTGTD TGVGKTEVAC ALVRAARAAG LDAVGMKPAQ SGHVAGEPSD AERLREASGG
     VEPLEAICPY TFAAPLAPAA AARAEGREVS LARVVEAARA LAARHAAVVV EGAGGLLVPL
     TARETHADLA AALGLPVLVV ARAGLGTVNH TALTVEALER RGLPIAGIVL NRTGPEDDPS
     VPLNAAEIAR LTHREPLALL PWEPDIARRA RALGSVLAAK IQF
//