Q2ILM6 (Q2ILM6_ANADE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193
EC=6.3.1.5 HAMAP MF_00193

Gene names

Name:	nadE HAMAP MF_00193
Ordered Locus Names:	Adeh_2788

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP] EMBL ABC82558.1

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193 SAAS SAAS003694
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193 SAAS SAAS003694
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_00193 SAAS SAAS003694 NAD SAAS SAAS003694 HAMAP MF_00193 Nucleotide-binding
Molecular function	Ligase SAAS SAAS003694 HAMAP MF_00193 EMBL ABC82558.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	38 – 45	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	40	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	Q2ILM6 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 6FEE5522BC801886	FASTA	323	36,092
	10 20 30 40 50 60 MVSRDVLGID ASRVAEEIER AVREQVLGTL RRRGAVVGMS GGIDSSVTAA LCVRALGKDR 70 80 90 100 110 120 VFGLMMPERD SSGDALRLGR MLAEHLGIRF AVEDVAPALD GLGCYARQLE AIRMVVPEYG 130 140 150 160 170 180 PGWKCKLTLP SILDADRLNI TALTVQDPEG NQRTQRMTAA AYLQMVAATN FKQRTRKMME 190 200 210 220 230 240 YYHADRLNYA VAGTPNLLEY DQGFFVKQGD GAADFKPIAH LYKTQVYALA EHLGVPEEIR 250 260 270 280 290 300 RRPPTTDTFS LSQTQEEFYF ALPYRDMDLC LWGLRNGKPA AEVAPALGLT AEQVERVYRD 310 320 IEAKRRVSVY LHHPPMLVSE RED

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2CP-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000251 Genomic DNA. Translation: ABC82558.1.
RefSeq	YP_465995.1. NC_007760.1.
3D structure databases
ProteinModelPortal	Q2ILM6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2ILM6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3890251.
GenomeReviews	Gene locus Adeh_2788 in contig CP000251_GR.
KEGG	ade:Adeh_2788.
PATRIC	20921795. VBIAnaDeh31384_2865.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0171.
HOGENOM	HBG351567.
OMA	AHLYKSQ.
ProtClustDB	PRK00876.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KO	K01916.
Pfam	PF02540. NAD_synthase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2ILM6_ANADE

Accession

Primary (citable) accession number: Q2ILM6

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)