Q2ILC5 (COAE_ANADE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase
EC=2.7.1.24

Alternative name(s):
Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	Adeh_2684

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity HAMAP MF_00376.
Sequence similarities	Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dephospho-CoA kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Dephospho-CoA kinase HAMAP MF_00376		PRO_0000243253
Regions
	Domain	3 – 206	204	DPCK
	Nucleotide binding	8 – 15	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2ILC5 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 26A649FACEC15C86	FASTA	211	22,334
	10 20 30 40 50 60 MRVIGLTGGI ATGKSTFAAL LRARGAPVVD ADALARAAVE PGTPALAEIA RTFGAEVLRP 70 80 90 100 110 120 DGALDRKALG ARVFADPGAR RRLEAITHPA VRLAMREETA RLAAQGHPLA FYDTPLLYEV 130 140 150 160 170 180 GLEALLDAVV VVWAPRDVQR ERLMRRDGLG GAEADARLAA QLPVDEKAAR ADFVVENAGA 190 200 210 PEALAGKADR LLADLRGGRG RRLPNAPPVR Y

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2CP-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000251 Genomic DNA. Translation: ABC82454.1.
RefSeq	YP_465891.1. NC_007760.1.
3D structure databases
ProteinModelPortal	Q2ILC5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2ILC5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3890358.
GenomeReviews	Gene locus Adeh_2684 in contig CP000251_GR.
KEGG	ade:Adeh_2684.
PATRIC	20921575. VBIAnaDeh31384_2756.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0237.
HOGENOM	HBG650290.
OMA	YVIMVVP.
PhylomeDB	Q2ILC5.
ProtClustDB	PRK00081.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_2684-MONOMER.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
KO	K00859.
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_ANADE

Accession

Primary (citable) accession number: Q2ILC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program