Reviewed, UniProtKB/Swiss-Prot Q2IL45 (KGUA_ANADE)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Adeh_2606

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Guanylate kinase HAMAP MF_00328		PRO_0000266284
Regions
	Domain	13 – 193	181	Guanylate kinase-like
	Nucleotide binding	20 – 27	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2IL45-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: C057634EC13609CD	FASTA	226	24,357
	10 20 30 40 50 60 MSSDAAAQER LPGLLLVLSA PSGAGKTTLA HRLREASPDA VFSISATTRA PRGAEREGVD 70 80 90 100 110 120 YHFVTAERFT ELVAQGAFAE WAEVHGQRYG TLRATVDEAL AAGKLALFDI DVQGGAQIKA 130 140 150 160 170 180 AWPQQAATVL VLPPDEAELE RRLRGRDTDS DETIRRRLVA ARAEVARGLG SYDYVVVNDV 190 200 210 220 LEGALAQLQA IVRHERLRHA GRWDPEAARV AEACRRSAAP LGGWAS

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC82376.1.
RefSeq	YP_465813.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IL45.
Genome annotation databases
GeneID	3889872.
GenomeReviews	Gene locus Adeh_2606 in contig CP000251_GR.
KEGG	ade:Adeh_2606.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IL45.
OMA	DIDWQGT.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_2606-MON.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_ANADE

Accession

Primary (citable) accession number: Q2IL45

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 7, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)