Reviewed, UniProtKB/Swiss-Prot Q2IKX7 (SYD_ANADE)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	Adeh_2533

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	603 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity. HAMAP MF_00044
Subcellular location	Cytoplasm HAMAP MF_00044.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 603	603	Aspartyl-tRNA synthetase HAMAP MF_00044		PRO_0000235506

Sequences

	Sequence		Length	Mass (Da)
	Q2IKX7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 9F2B7073E523FFE9	FASTA	603	67,990
	10 20 30 40 50 60 MPRFITELKR THSCGELTKA DIGKEVVLFG WVNNRRDHGG AVFIDLRDRA GLTQVVFEED 70 80 90 100 110 120 VRPDVHELAG QLRLEYCVGV RGKVVSRGGN VNPKLPTGEI EVHASDLEIF NRSEPAPFQI 130 140 150 160 170 180 EDKIDTGEEK RLQYRYLDLR RAPLQQTLMT RAKVNHLTRN YFTDKGFLEL ETPFMVKYTP 190 200 210 220 230 240 GGARNFLVPS RLNPGKFYAL AESPQLFKQL YMMAGFDRYF QIVRCFRDED LRLDRQPEFT 250 260 270 280 290 300 QIDVEMSFVE QNDVFDVMEG LVVKLWKEVL GIEIPRPFQR MPFEESMAKY GNDKPDLRFD 310 320 330 340 350 360 MPHVVLTDLV RQHDGGGVPL MHEAVKAKGI VKAMRVPASA NFSRTEIDKL EEYVKGMGAK 370 380 390 400 410 420 GLARAKVGEG GEWTQSPLAK TITPALRQAI NDACEAKAGD LLLFQFGKES VVHTVMANLR 430 440 450 460 470 480 VHLAKRMGLI PEYGSGGAWR FLWVVNPPLF EYDEESGQWA AAHHAFTRPH DSDLQFLESD 490 500 510 520 530 540 PGKVNCYRYD LVLNGFEIGG GSIRLHDPEV QARVFKAMGI SDEEARSKFG FLLDALKMGA 550 560 570 580 590 600 PPHGGIALGM DRLVMLLTGA ESLRDVVAWP KTQKGTDLMT GAPGDVDARQ LRELYVKSTF EPK

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000251 Genomic DNA. Translation: ABC82303.1.
RefSeq	YP_465740.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IKX7.
Genome annotation databases
GeneID	3890134.
GenomeReviews	Gene locus Adeh_2533 in contig CP000251_GR.
KEGG	ade:Adeh_2533.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0173.
HOGENOM	HBG396032.
OMA	PLFEYDE.
PhylomeDB	Q2IKX7.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_2533-MONOMER.
Family and domain databases
HAMAP	MF_00044_B. Asp_tRNA_synth_B. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-dom. IPR002312. Asp-tRNA-synth_IIb. IPR020564. Asp-tRNA-synth_IIb_bac-type. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_ANADE

Accession

Primary (citable) accession number: Q2IKX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	March 7, 2006
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)