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Q2IKQ7

- PUR9_ANADE

UniProt

Q2IKQ7 - PUR9_ANADE

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Adeh_2468
Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-2499-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Adeh_2468
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
Taxonomic identifieri290397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000001935: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018834Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290397.Adeh_2468.

Structurei

3D structure databases

ProteinModelPortaliQ2IKQ7.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2IKQ7-1 [UniParc]FASTAAdd to Basket

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MTRRALVSVS DKTGLVPFAR RLAALGVELL STGGTQKALA EAGVPVTGVG    50
DYTQAPEILG GRVKTLHPRV HGGILYRRGL ASDEADVKAR DIPPIDLVVV 100
NLYPFREAVA AGKPFETCVE EIDIGGPTMV RSAAKNSAHV GVVVDPADYD 150
KVAAELEATR ALSDATRFYL MKKAFAHTAA YDAAISEYLT ARETPEAAPA 200
HFPATLAAVY TKAYDLRYGE NPHQAGAFYR AAREPEEPSV AFAQVLQGKE 250
LSYNNLLDLQ AALAGVMEFD ETACVVIKHN TPCGVSTGRT AGEAFARARE 300
CDPVSAFGGI VALNRPVDEA TASELTSLFL ECVIAPGYDA AARAALAVKK 350
NLRLLEAPRL GAARATWRRR PEEGRELRSI PGGLLVMDRD LGSVRREDCK 400
VMTKRAPTEQ EWKDLLFAWK VVKHVKSNAI VFAKDDRTVA IGGGQTSRVE 450
SVKTAVMKAA LDVRGSSVGS DAFFPFADGV EEIIKAGATA IIQPGGSMRD 500
AEVIAAADKA GIAMVATGMR HFRH 524
Length:524
Mass (Da):55,984
Last modified:March 7, 2006 - v1
Checksum:i81A77AAAD34769E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000251 Genomic DNA. Translation: ABC82238.1.
RefSeqiYP_465675.1. NC_007760.1.

Genome annotation databases

EnsemblBacteriaiABC82238; ABC82238; Adeh_2468.
GeneIDi3890166.
KEGGiade:Adeh_2468.
PATRICi20921103. VBIAnaDeh31384_2529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000251 Genomic DNA. Translation: ABC82238.1 .
RefSeqi YP_465675.1. NC_007760.1.

3D structure databases

ProteinModelPortali Q2IKQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290397.Adeh_2468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC82238 ; ABC82238 ; Adeh_2468 .
GeneIDi 3890166.
KEGGi ade:Adeh_2468.
PATRICi 20921103. VBIAnaDeh31384_2529.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci ADEH290397:GI2Z-2499-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-C.

Entry informationi

Entry nameiPUR9_ANADE
AccessioniPrimary (citable) accession number: Q2IKQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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