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Protein

D-alanine--D-alanine ligase

Gene

Adeh_2449

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-2480-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Adeh_2449Imported
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)Imported
Taxonomic identifieri290397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001935 Componenti: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi290397.Adeh_2449.

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000002979.
KOiK01921.
OMAiPMEIVFL.
OrthoDBiEOG66MQKK.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.30.470.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 2 hits.
PROSITEiPS50975. ATP_GRASP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2IKN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIALTHNLR ISDSEEEAEF DTRETVDALA GAIERLGHRV ERIEVSGPAS
60 70 80 90 100
RTVTRLEAFG PDLIFNTAEG RRGRFREAFF PALFDELGMP YTGSDAYALA
110 120 130 140 150
VTLDKQLTKL VLAQKGVRTP RWQYVEEPWQ LQVNALRYPV IVKPNFEGSS
160 170 180 190 200
KGITQDSVVD DPVRLHEVVQ DGLARYPAGL LVEEFVVGRD LTVPFLEAAA
210 220 230 240 250
PDRHGVLQPV EYVIDPAVTA GRKYAIYDYE LKTKLDKAVS VRAPAKVKRA
260 270 280 290 300
QAERIQQLCE TVYRELGIRD LGRIDLRLGD DGELYFLEIN ALPSLEPGAG
310 320 330 340 350
IYAAAALEGL HEDAVLGAVI QSAVQRWNIV DKSARRGRPR RTERLKVGFS
360 370 380 390 400
FNVKRVTPDP GGEQDEEAEY DSPKTLQAIR EAIASWGHEV VDLEATQDLP
410 420 430 440 450
LQLASTPVDV VFNIAEGFKG RSRESQVPSL LELLDIPYTG SDPSALSVSL
460 470 480 490 500
DKALAKRMVR THGILTPDYL VLNTGNERLP RELTFPLIVK PVAEGTSKGV
510 520 530 540 550
TRKSVVRDEL ELREVARELI AKYRQPALAE GYVSGREFTV GLLGERRPRV
560 570 580 590 600
LPPMEIVFLD AKDPTPIYSF EMKQDWSERI RYEVPAKLSP RELDRLEKAA
610 620 630 640 650
RECFTALGCR DVARLDFRMD AEGRIHFIEC NPLPGLAPGW SDLVLIAQAA
660 670 680 690 700
GMDYRGLIGE ILSFAIRRYQ ERERERERAR RAQAAAEREA QASAPANGAP
710 720
GGESPAGGNG GAGGEAGERR PQAPHRH
Length:727
Mass (Da):80,700
Last modified:March 7, 2006 - v1
Checksum:i4704C10BCF537848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC82219.1.
RefSeqiYP_465656.1. NC_007760.1.

Genome annotation databases

EnsemblBacteriaiABC82219; ABC82219; Adeh_2449.
KEGGiade:Adeh_2449.
PATRICi20921063. VBIAnaDeh31384_2509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC82219.1.
RefSeqiYP_465656.1. NC_007760.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290397.Adeh_2449.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC82219; ABC82219; Adeh_2449.
KEGGiade:Adeh_2449.
PATRICi20921063. VBIAnaDeh31384_2509.

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000002979.
KOiK01921.
OMAiPMEIVFL.
OrthoDBiEOG66MQKK.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciADEH290397:GI2Z-2480-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.30.470.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 2 hits.
PROSITEiPS50975. ATP_GRASP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-CImported.

Entry informationi

Entry nameiQ2IKN7_ANADE
AccessioniPrimary (citable) accession number: Q2IKN7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: April 1, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.