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Q2IK16

- MDH2_ANADE

UniProt

Q2IK16 - MDH2_ANADE

Protein

Malate dehydrogenase 2

Gene

mdh2

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei83 – 831SubstrateUniRule annotation
    Binding sitei89 – 891SubstrateUniRule annotation
    Binding sitei96 – 961NADUniRule annotation
    Binding sitei121 – 1211SubstrateUniRule annotation
    Binding sitei152 – 1521SubstrateUniRule annotation
    Active sitei176 – 1761Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADUniRule annotation
    Nucleotide bindingi119 – 1213NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciADEH290397:GI2Z-2255-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase 2UniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdh2UniRule annotation
    Ordered Locus Names:Adeh_2226
    OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
    Taxonomic identifieri290397 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000001935: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Malate dehydrogenase 2PRO_0000241940Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290397.Adeh_2226.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2IK16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiLDLMEAQ.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2IK16-1 [UniParc]FASTAAdd to Basket

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    MARSKIALIG GGQIGGVLAQ LAALRELGDV VLFDIVEGLP QGKTLDIAEA    50
    APVDGFDVSL KGTNTYEDIK GADVVIVTAG LPRKPGMSRD DLIAVNSKIM 100
    TTVAEGIKQY APNAFVIVIS NPLDAMVTLC QRITGFPHNR VVGQAGVLDS 150
    ARFAAFIAWE LGVSVKDVTA VTLGGHGDDM VPLVRYTSVC GVPVMELLEQ 200
    KYGAAKAAEV MAAMVKRTRG AGGEVVALLK TGSAFYSPAS SAIAMAESFL 250
    KDQKRVLPTC AFLKGEFGVD GLYVGVPVVI GAGGAERVLQ LKLNAEEQAM 300
    MDKSVKAVKD LVATLK 316
    Length:316
    Mass (Da):33,020
    Last modified:March 7, 2006 - v1
    Checksum:i5DFE384EA886C555
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000251 Genomic DNA. Translation: ABC81996.1.
    RefSeqiYP_465433.1. NC_007760.1.

    Genome annotation databases

    EnsemblBacteriaiABC81996; ABC81996; Adeh_2226.
    GeneIDi3889615.
    KEGGiade:Adeh_2226.
    PATRICi20920617. VBIAnaDeh31384_2288.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000251 Genomic DNA. Translation: ABC81996.1 .
    RefSeqi YP_465433.1. NC_007760.1.

    3D structure databases

    ProteinModelPortali Q2IK16.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290397.Adeh_2226.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC81996 ; ABC81996 ; Adeh_2226 .
    GeneIDi 3889615.
    KEGGi ade:Adeh_2226.
    PATRICi 20920617. VBIAnaDeh31384_2288.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi LDLMEAQ.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci ADEH290397:GI2Z-2255-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2CP-C.

    Entry informationi

    Entry nameiMDH2_ANADE
    AccessioniPrimary (citable) accession number: Q2IK16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3