Reviewed, UniProtKB/Swiss-Prot Q2IJB7 (ILVC_ANADE)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	Adeh_1976

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Ketol-acid reductoisomerase		PRO_0000252750
Sites
	Active site	108	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2IJB7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: C80BF94BC7301A6F	FASTA	341	37,127
	10 20 30 40 50 60 MATIYYDKDA NLDLLKKRKV AIIGYGSQGH AHALNLRDSG VDVRVGLAAG SKSKAKAEGA 70 80 90 100 110 120 GLRVLSVAEA SKEADVIMVL IPDQTQKKVY DEEIAPHLSK GKALLFAHGF NIHFVQVRPP 130 140 150 160 170 180 PDVDVLLVAP KGPGHMVRRQ YQDGRGIPGL VAVHQDATGQ AKAVGLAYAR GIGCTRAGVL 190 200 210 220 230 240 ETTFKEETET DLFGEQAVLC GGAAALVKNG FEVLVEAGYQ PESAYFECLH ELKLIVDLMY 250 260 270 280 290 300 EGGLAWMRHS ISDTAEYGDY TRGPRVVDGR SKDEMRKILK EIQGGHFAKE FILENQAGGP 310 320 330 340 TMARYRAAEA AHPIEEVGKR LRDMMSWIRE AKKDSSDPGS R

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC81747.1.
RefSeq	YP_465184.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3887199.
GenomeReviews	Gene locus Adeh_1976 in contig CP000251_GR.
KEGG	ade:Adeh_1976.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IJB7.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_1976-MON.
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_ANADE

Accession

Primary (citable) accession number: Q2IJB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	March 7, 2006
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)