ID   TRMD_ANADE              Reviewed;         247 AA.
AC   Q2IJ54;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE            EC=2.1.1.31;
DE   AltName: Full=M1G-methyltransferase;
DE   AltName: Full=tRNA [GM37] methyltransferase;
GN   Name=trmD; OrderedLocusNames=Adeh_1913;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(1)-methylguanine.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase trmD family.
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DR   EMBL; CP000251; ABC81684.1; -; Genomic_DNA.
DR   RefSeq; YP_465121.1; -.
DR   GeneID; 3887577; -.
DR   GenomeReviews; CP000251_GR; Adeh_1913.
DR   KEGG; ade:Adeh_1913; -.
DR   HOGENOM; Q2IJ54; -.
DR   OMA; Q2IJ54; HRSVDDT.
DR   BioCyc; ADEH290397:ADEH_1913-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0009019; F:tRNA (guanine-N1-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_00605; -; 1.
DR   InterPro; IPR016009; tRNA_m1G_MeTrfase.
DR   InterPro; IPR002649; tRNA_m1G_MeTrfase_bac.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   PIRSF; PIRSF000386; tRNA_mtase; 1.
DR   ProDom; PD004978; tRNA_m1G_mtfrase; 1.
DR   TIGRFAMs; TIGR00088; trmD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing.
FT   CHAIN         1    247       tRNA (guanine-N(1)-)-methyltransferase.
FT                                /FTId=PRO_0000257388.
FT   REGION      134    139       S-adenosyl-L-methionine binding (By
FT                                similarity).
FT   BINDING     115    115       S-adenosyl-L-methionine; via amide
FT                                nitrogen (By similarity).
SQ   SEQUENCE   247 AA;  26889 MW;  F93A857E36442DCE CRC64;
     MARLEVDILT LFPRMCAGYL GESILGKAQE AGLLAATITD IRDHATGKHR VCDDAPYGGG
     AGMVMKPEPL VEAIEAARAR LPGAWVVLTS PRGARLDQAL ARRFAEHGRL ILACGRYEGV
     DERVMTAVDM QVSIGDFVLT GGELAALCVV DAAARLVPGV LGNAASADAE SFAGAEGLLE
     YPQYTRPPEF RGMRVPEVLL SGDHRRIERW RRREALRATR ERRPDLFTRV SLPESDLRLI
     DAGDDEL
//