ID   HUTH_ANADE              Reviewed;         508 AA.
AC   Q2IIV4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Histidine ammonia-lyase;
DE            Short=Histidase;
DE            EC=4.3.1.3;
GN   Name=hutH; OrderedLocusNames=Adeh_1814;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-histidine = urocanate + NH(3).
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO),
CC       which is formed autocatalytically by cyclization and dehydration
CC       of residues Ala-Ser-Gly (By similarity).
CC   -!- SIMILARITY: Belongs to the PAL/histidase family.
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DR   EMBL; CP000251; ABC81586.1; -; Genomic_DNA.
DR   RefSeq; YP_465023.1; -.
DR   GeneID; 3887396; -.
DR   GenomeReviews; CP000251_GR; Adeh_1814.
DR   KEGG; ade:Adeh_1814; -.
DR   HOGENOM; Q2IIV4; -.
DR   OMA; Q2IIV4; FAPDIEA.
DR   BioCyc; ADEH290397:ADEH_1814-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016211; F:ammonia ligase activity; IEA:InterPro.
DR   GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:HAMAP.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006548; P:histidine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00229; -; 1.
DR   InterPro; IPR005921; HutH.
DR   InterPro; IPR001106; Phe/His_NH3-lyase.
DR   Pfam; PF00221; PAL; 1.
DR   TIGRFAMs; TIGR01225; hutH; 1.
DR   PROSITE; PS00488; PAL_HISTIDASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Histidine metabolism; Lyase.
FT   CHAIN         1    508       Histidine ammonia-lyase.
FT                                /FTId=PRO_0000336582.
FT   MOD_RES     144    144       2,3-didehydroalanine (Ser) (By
FT                                similarity).
FT   CROSSLNK    143    145       5-imidazolinone (Ala-Gly) (By
FT                                similarity).
SQ   SEQUENCE   508 AA;  53101 MW;  52FF0095D52F0AD5 CRC64;
     METLLLDGET LTLEQVRAVA TGAARAALAP AARERVRRSR ALVDARLEDG EAHYGINTGF
     GTLAEVRIPR ADLERLQRNL VLSHAAGVGA PLPLAEARAL VLLRANVLAK GVSGIRERTL
     ELLLAMLERG VVPVVPERGS VGASGDLAPL AHLALVLIGD GEAFLAPPGA AAPPERLPGG
     EALRRAGLEP VVLQPKEGLA LVNGTQAMAA VGTLALLRAE RLAALADLAG AMTLEGLLGS
     HRPFAPEIQA ARGQPGQIEA AAHLRALLAG SELNASHQGP GCHKVQDPYS LRCMPQVHGA
     ARDGIGFCRG VLAREVNAAT DNPLVFPDTG EIVSGGNFHG QPVALALDVL AVAASHLAAI
     SERRVEQLVN PSLSGLPPFL APQHGLNSGF MIAQVTSAAL VSENKVLCHP ASVDSIPSSA
     GREDHVSMGM TAALKARQVV ENVRTCLAIE LLVAAQALDL RAPLRPAQRV ADAHARLRER
     VPHLSEDRAL YRDIEAVSRL VDEGALEL
//