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Q2IIC2

- MDH1_ANADE

UniProt

Q2IIC2 - MDH1_ANADE

Protein

Malate dehydrogenase 1

Gene

mdh1

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351NADUniRule annotation
    Binding sitei86 – 861SubstrateUniRule annotation
    Binding sitei92 – 921SubstrateUniRule annotation
    Binding sitei99 – 991NADUniRule annotation
    Binding sitei124 – 1241SubstrateUniRule annotation
    Binding sitei155 – 1551SubstrateUniRule annotation
    Active sitei179 – 1791Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADUniRule annotation
    Nucleotide bindingi122 – 1243NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciADEH290397:GI2Z-1650-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase 1UniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdh1UniRule annotation
    Ordered Locus Names:Adeh_1626
    OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
    Taxonomic identifieri290397 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000001935: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Malate dehydrogenase 1PRO_0000241939Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290397.Adeh_1626.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2IIC2.
    SMRiQ2IIC2. Positions 4-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiKTYAKDA.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2IIC2-1 [UniParc]FASTAAdd to Basket

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    MAQRKKIALI GAGQIGGTLA LLAGQKELGD VVLVDIMEGV AKGKALDLQE    50
    TRGVGKWDVD VTGGGTTDYS VIRDADVCIV TAGVPRKPGM SREDLLKVNL 100
    DAITKVAHGI KQYAPNAFVI VITNPLDSMV YAMYKVTGFP KNRVVGMAGV 150
    LDTARFQYFV GDAAGVSPQD VQAMVLGGHG DDMVPLLRYS SVAGVPLTRL 200
    LDKAKLDAIV ERTRKGGGEI VALLGTGSAF YAPAASAIAM AESYLRDKKR 250
    VLPCSALLEG QYGVKGLFVG VPVVIGAGGV ERVLELELND DERAMLQRSV 300
    DSVKKSVAET KL 312
    Length:312
    Mass (Da):32,915
    Last modified:March 7, 2006 - v1
    Checksum:iEC486A2D26D3E1CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000251 Genomic DNA. Translation: ABC81399.1.
    RefSeqiWP_011420682.1. NC_007760.1.
    YP_464836.1. NC_007760.1.

    Genome annotation databases

    EnsemblBacteriaiABC81399; ABC81399; Adeh_1626.
    GeneIDi3888125.
    KEGGiade:Adeh_1626.
    PATRICi20919399. VBIAnaDeh31384_1682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000251 Genomic DNA. Translation: ABC81399.1 .
    RefSeqi WP_011420682.1. NC_007760.1.
    YP_464836.1. NC_007760.1.

    3D structure databases

    ProteinModelPortali Q2IIC2.
    SMRi Q2IIC2. Positions 4-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290397.Adeh_1626.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC81399 ; ABC81399 ; Adeh_1626 .
    GeneIDi 3888125.
    KEGGi ade:Adeh_1626.
    PATRICi 20919399. VBIAnaDeh31384_1682.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi KTYAKDA.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci ADEH290397:GI2Z-1650-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2CP-C.

    Entry informationi

    Entry nameiMDH1_ANADE
    AccessioniPrimary (citable) accession number: Q2IIC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3