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Q2IIC2

- MDH1_ANADE

UniProt

Q2IIC2 - MDH1_ANADE

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Protein

Malate dehydrogenase 1

Gene

mdh1

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NADUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei92 – 921SubstrateUniRule annotation
Binding sitei99 – 991NADUniRule annotation
Binding sitei124 – 1241SubstrateUniRule annotation
Binding sitei155 – 1551SubstrateUniRule annotation
Active sitei179 – 1791Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADUniRule annotation
Nucleotide bindingi122 – 1243NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-1650-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 1UniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdh1UniRule annotation
Ordered Locus Names:Adeh_1626
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
Taxonomic identifieri290397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001935: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Malate dehydrogenase 1PRO_0000241939Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290397.Adeh_1626.

Structurei

3D structure databases

ProteinModelPortaliQ2IIC2.
SMRiQ2IIC2. Positions 4-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiKTYAKDA.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2IIC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQRKKIALI GAGQIGGTLA LLAGQKELGD VVLVDIMEGV AKGKALDLQE
60 70 80 90 100
TRGVGKWDVD VTGGGTTDYS VIRDADVCIV TAGVPRKPGM SREDLLKVNL
110 120 130 140 150
DAITKVAHGI KQYAPNAFVI VITNPLDSMV YAMYKVTGFP KNRVVGMAGV
160 170 180 190 200
LDTARFQYFV GDAAGVSPQD VQAMVLGGHG DDMVPLLRYS SVAGVPLTRL
210 220 230 240 250
LDKAKLDAIV ERTRKGGGEI VALLGTGSAF YAPAASAIAM AESYLRDKKR
260 270 280 290 300
VLPCSALLEG QYGVKGLFVG VPVVIGAGGV ERVLELELND DERAMLQRSV
310
DSVKKSVAET KL
Length:312
Mass (Da):32,915
Last modified:March 7, 2006 - v1
Checksum:iEC486A2D26D3E1CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC81399.1.
RefSeqiYP_464836.1. NC_007760.1.

Genome annotation databases

EnsemblBacteriaiABC81399; ABC81399; Adeh_1626.
GeneIDi3888125.
KEGGiade:Adeh_1626.
PATRICi20919399. VBIAnaDeh31384_1682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC81399.1 .
RefSeqi YP_464836.1. NC_007760.1.

3D structure databases

ProteinModelPortali Q2IIC2.
SMRi Q2IIC2. Positions 4-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290397.Adeh_1626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC81399 ; ABC81399 ; Adeh_1626 .
GeneIDi 3888125.
KEGGi ade:Adeh_1626.
PATRICi 20919399. VBIAnaDeh31384_1682.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi KTYAKDA.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci ADEH290397:GI2Z-1650-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-C.

Entry informationi

Entry nameiMDH1_ANADE
AccessioniPrimary (citable) accession number: Q2IIC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3