Reviewed, UniProtKB/Swiss-Prot Q2IIC1 (SUCC_ANADE)

Names and origin

Protein names

Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit beta
    EC=6.2.1.5
Alternative name(s):
    Succinyl-CoA synthetase subunit beta
      Short name=SCS-beta

Gene names

Name:	sucC
Ordered Locus Names:	Adeh_1627

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP MF_00558		PRO_1000081998
Regions
	Domain	9 – 244	236	ATP-grasp
	Nucleotide binding	35 – 108	74	ATP By similarity
Sites
	Metal binding	197	1	Magnesium or manganese By similarity
	Metal binding	199	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2IIC1-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: FAE0F6484F961408	FASTA	388	41,122
	10 20 30 40 50 60 MKIHEYQAKE ILRKFGVAVP RGYLAVTPLE AEGAARQLGG GISAVKAQIH AGGRGKGGGV 70 80 90 100 110 120 KLARSPDEAR QHAEAMLGMM LKTPQTGPEG QEVRKVYVEE GCRIARELYL GMTLDREIGR 130 140 150 160 170 180 LAVMASVEGG VDIEEVAAKH PDKILREWIS PLTGLMPFQA RRLAFGLGLS GDSVTAFVRF 190 200 210 220 230 240 ATGLYNAYVA TDASLAEINP LVITVGGEVL ALDAKMNFDD NALYRHPDIA AMRDPDEEDP 250 260 270 280 290 300 KETQAKEYDL SYIALDGDIG CMVNGAGLAM ATMDVIKLSG GQPANFLDVG GGADEDKVTA 310 320 330 340 350 360 AFKIILSDPH VKAVLVNIFG GIMKCDVIAN GIVAAAKQVG LSIPLVVRLE GTNVELGKEI 370 380 LAHSELKIIP ADDLGEAARK AVQAARAA

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC81400.1.
RefSeq	YP_464837.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3888126.
GenomeReviews	Gene locus Adeh_1627 in contig CP000251_GR.
KEGG	ade:Adeh_1627.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IIC1.
OMA	Q2IIC1. NLHCLDA.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_1627-MON.
Family and domain databases
HAMAP	MF_00558. [Tree]
InterPro	IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. False negative. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC_ANADE

Accession

Primary (citable) accession number: Q2IIC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)