Reviewed, UniProtKB/Swiss-Prot Q2IIB1 (PYRB_ANADE)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Adeh_1618

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Aspartate carbamoyltransferase		PRO_0000321070

Sequences

	Sequence		Length	Mass (Da)
	Q2IIB1-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 85ADCBBCDDCE1EA6	FASTA	313	33,588
	10 20 30 40 50 60 MIGRHKHCIA LEDFSREEIL EVIDLAVSMK EVLQRPIKKV PSLRGKMVVN LFFEASTRTR 70 80 90 100 110 120 SSFETAAKIL SADALNWTSS SSSVTKGETL VDTAKNLEAM RPDVLVIRHS AGGAPRLVAE 130 140 150 160 170 180 HVGCSVVSAG DGAHEHPSQG LLDCFTLREK LGTLEGKTVA IVGDVSHSRV ARSDLHAFPK 190 200 210 220 230 240 LGAKVRLCGP PTMMPAGVER LGATVHTDLR EAVDGADAVI MLRIQHERIG DPLIPGTREY 250 260 270 280 290 300 SKVWGLNAKK AADWLKPSCV ILHPGPINRG VELSPEVADG PRSVILDQVQ NGVAVRMAIL 310 YLLAGGAGEE ARA

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC81391.1.
RefSeq	YP_464828.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3888117.
GenomeReviews	Gene locus Adeh_1618 in contig CP000251_GR.
KEGG	ade:Adeh_1618.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IIB1.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_1618-MON.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ANADE

Accession

Primary (citable) accession number: Q2IIB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 7, 2006
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)