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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotationSAAS annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531NucleophileUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation, LyaseImported

Keywords - Biological processi

tRNA processingUniRule annotation

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-1562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:Adeh_1544Imported
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)Imported
Taxonomic identifieri290397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001935 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290397.Adeh_1544.

Structurei

3D structure databases

ProteinModelPortaliQ2II39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0101.
HOGENOMiHOG000248674.
KOiK06173.
OMAiGPSFHAR.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2II39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRSYALRL AYDGGRFRGF QRQPGLPTVQ QALEEALERL GVRAQLHVAA
60 70 80 90 100
RTDAGVHALA QVVSFSARAA LDPAALRRGL NEGLPEGILV LDAARVGPSF
110 120 130 140 150
HARGSAASRT YVYLVGAPPP EGLRPYAWTL PDARAFPELA EVPPLDAAAM
160 170 180 190 200
REALGAAVGE HDFVGFARPG EQRGTVRTLL RAEVVEAGWA PLVAVVLEGK
210 220 230 240 250
GFLRAMVRNL VGTAVAVGLG RAPPDVIRTL LATRGRYRGV RAPGWGLTLA
260 270
AVRYPDGAWP SPAAPPDPAA SR
Length:272
Mass (Da):28,851
Last modified:March 7, 2006 - v1
Checksum:i3F9044D34321EA21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC81317.1.
RefSeqiWP_011420600.1. NC_007760.1.

Genome annotation databases

EnsemblBacteriaiABC81317; ABC81317; Adeh_1544.
KEGGiade:Adeh_1544.
PATRICi20919211. VBIAnaDeh31384_1594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC81317.1.
RefSeqiWP_011420600.1. NC_007760.1.

3D structure databases

ProteinModelPortaliQ2II39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290397.Adeh_1544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC81317; ABC81317; Adeh_1544.
KEGGiade:Adeh_1544.
PATRICi20919211. VBIAnaDeh31384_1594.

Phylogenomic databases

eggNOGiCOG0101.
HOGENOMiHOG000248674.
KOiK06173.
OMAiGPSFHAR.
OrthoDBiEOG6Z9B4R.

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-1562-MONOMER.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-CImported.

Entry informationi

Entry nameiQ2II39_ANADE
AccessioniPrimary (citable) accession number: Q2II39
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: July 22, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.