Reviewed, UniProtKB/Swiss-Prot Q2IHZ6 (HUTI_ANADE)

Names and origin

Protein names

Recommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	Adeh_1507

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Imidazolonepropionase HAMAP MF_00372		PRO_0000306424
Sites
	Metal binding	76	1	Zinc or iron By similarity
	Metal binding	78	1	Zinc or iron By similarity
	Metal binding	247	1	Zinc or iron By similarity
	Metal binding	322	1	Zinc or iron By similarity
	Binding site	85	1	Substrate By similarity
	Binding site	98	1	Substrate By similarity
	Binding site	148	1	Substrate By similarity
	Binding site	182	1	Substrate By similarity
	Binding site	250	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2IHZ6-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 89EA666B75B8992F	FASTA	421	43,894
	10 20 30 40 50 60 MSRPAATLVL RNAVVATCDR GPSDAGLLPG AAVAVEGRRV AWVGRERDVE AEVNLAGAQV 70 80 90 100 110 120 IDARGGLVTP GLVDSHTHLV FAGERAGEFA LRCAGRTYLQ VALSGGGIAV TTRETRAAPD 130 140 150 160 170 180 EQLLAAAAAR ARRLIAQGVT TLEVKSGYGL DAPEELRLLR IVHQLGRALG GDATILPTLL 190 200 210 220 230 240 FHAVPPEQVG DRAGFVRDAC ASLIPQVARE RLAQFCDVFV EDGAFAPDEA RLLLQAAKDR 250 260 270 280 290 300 GLVPRVHAEQ LTAGGGARLA AELGCSSADH LEELDDAGIA ALAQARVVAG LLPLSTLFLG 310 320 330 340 350 360 SERYAPARRL LEAGVPVSLA TNMNPGSAMS ENVGLTLSLA CLKLRLTPAE ALVAFTAGGA 370 380 390 400 410 420 RALRQPDLGR VARGADADLV LWGCGSPEHL AWHMAVNHAL VVVKHGRVVH EAPPAAMVDC R

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC81280.1.
RefSeq	YP_464717.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3887917.
GenomeReviews	Gene locus Adeh_1507 in contig CP000251_GR.
KEGG	ade:Adeh_1507.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IHZ6.
OMA	Q2IHZ6. MNMACTL.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_1507-MON.
Family and domain databases
HAMAP	MF_00372. [Tree]
InterPro	IPR013108. Amidohydro_3. IPR005920. HutI. [Graphical view]
Pfam	PF07969. Amidohydro_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_ANADE

Accession

Primary (citable) accession number: Q2IHZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)