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Q2IH69

- DNLI_ANADE

UniProt

Q2IH69 - DNLI_ANADE

Protein

Probable DNA ligase

Gene

lig

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei213 – 2131ATPUniRule annotation
    Active sitei215 – 2151N6-AMP-lysine intermediateUniRule annotation
    Binding sitei220 – 2201ATPUniRule annotation
    Binding sitei235 – 2351ATPUniRule annotation
    Binding sitei264 – 2641ATPUniRule annotation
    Binding sitei304 – 3041ATPUniRule annotation
    Binding sitei376 – 3761ATPUniRule annotation
    Binding sitei382 – 3821ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciADEH290397:GI2Z-4218-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Adeh_4160
    OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
    Taxonomic identifieri290397 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000001935: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Probable DNA ligasePRO_0000365216Add
    BLAST

    Proteomic databases

    PRIDEiQ2IH69.

    Interactioni

    Protein-protein interaction databases

    STRINGi290397.Adeh_4160.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2IH69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiIQSSPRY.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2IH69-1 [UniParc]FASTAAdd to Basket

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    MLLAELAEVS RAVAATPARL EKIARLADAL GRLAPDERAV GASWLAGDLP    50
    GGRVGIGAAT LRAALEAAPP ERSGPGLTVA EVDAALRRIA AVAGPGSGAA 100
    RRRELDALLA RAGNPERRFL AALVLGELRQ GALEGVLADA VAKAAGLPAA 150
    EVRRAAMLAG ALPPVAEAAL SEGAAGLARF RLRVGEPVSP MLAQTAADVD 200
    EALRALGGEA ALEWKLDGAR IQAHRDGEAV RVFSRSLRDV TAAVPEVVAL 250
    LRAAPEPRLV LDGEAIALRA DGTPEPFQVT MRRFGRKLDV ERLAPELPLT 300
    AFFFDALVAG GAELLARPER ERWAALARAI PAERRVPRLV TRDPAEARAF 350
    LEDALARGQE GVVAKALDAP YEAGRRGAAW LKVKRAHTLD LVVLAAEWGS 400
    GRRRGWLSNL HLGARDPASG GFVMLGKTFK GMTDAMLAWQ TDRLKALATG 450
    PLDAWQVPVR PELVVEVAFD GIQSSPRYPG GLALRFARVK RYREDKRPED 500
    ADTIETVRGL YGG 513
    Length:513
    Mass (Da):54,363
    Last modified:March 7, 2006 - v1
    Checksum:i96017811B13D10FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000251 Genomic DNA. Translation: ABC83924.1.
    RefSeqiYP_467361.1. NC_007760.1.

    Genome annotation databases

    EnsemblBacteriaiABC83924; ABC83924; Adeh_4160.
    GeneIDi3887980.
    KEGGiade:Adeh_4160.
    PATRICi20924608. VBIAnaDeh31384_4257.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000251 Genomic DNA. Translation: ABC83924.1 .
    RefSeqi YP_467361.1. NC_007760.1.

    3D structure databases

    ProteinModelPortali Q2IH69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290397.Adeh_4160.

    Proteomic databases

    PRIDEi Q2IH69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC83924 ; ABC83924 ; Adeh_4160 .
    GeneIDi 3887980.
    KEGGi ade:Adeh_4160.
    PATRICi 20924608. VBIAnaDeh31384_4257.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi IQSSPRY.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci ADEH290397:GI2Z-4218-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2CP-C.

    Entry informationi

    Entry nameiDNLI_ANADE
    AccessioniPrimary (citable) accession number: Q2IH69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3