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Q2IH69 (DNLI_ANADE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Adeh_4160
OrganismAnaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]
Taxonomic identifier290397 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000365216

Sites

Active site2151N6-AMP-lysine intermediate By similarity
Binding site2131ATP By similarity
Binding site2201ATP By similarity
Binding site2351ATP By similarity
Binding site2641ATP By similarity
Binding site3041ATP By similarity
Binding site3761ATP By similarity
Binding site3821ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2IH69 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 96017811B13D10FB

FASTA51354,363
        10         20         30         40         50         60 
MLLAELAEVS RAVAATPARL EKIARLADAL GRLAPDERAV GASWLAGDLP GGRVGIGAAT 

        70         80         90        100        110        120 
LRAALEAAPP ERSGPGLTVA EVDAALRRIA AVAGPGSGAA RRRELDALLA RAGNPERRFL 

       130        140        150        160        170        180 
AALVLGELRQ GALEGVLADA VAKAAGLPAA EVRRAAMLAG ALPPVAEAAL SEGAAGLARF 

       190        200        210        220        230        240 
RLRVGEPVSP MLAQTAADVD EALRALGGEA ALEWKLDGAR IQAHRDGEAV RVFSRSLRDV 

       250        260        270        280        290        300 
TAAVPEVVAL LRAAPEPRLV LDGEAIALRA DGTPEPFQVT MRRFGRKLDV ERLAPELPLT 

       310        320        330        340        350        360 
AFFFDALVAG GAELLARPER ERWAALARAI PAERRVPRLV TRDPAEARAF LEDALARGQE 

       370        380        390        400        410        420 
GVVAKALDAP YEAGRRGAAW LKVKRAHTLD LVVLAAEWGS GRRRGWLSNL HLGARDPASG 

       430        440        450        460        470        480 
GFVMLGKTFK GMTDAMLAWQ TDRLKALATG PLDAWQVPVR PELVVEVAFD GIQSSPRYPG 

       490        500        510 
GLALRFARVK RYREDKRPED ADTIETVRGL YGG 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2CP-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000251 Genomic DNA. Translation: ABC83924.1.
RefSeqYP_467361.1. NC_007760.1.

3D structure databases

ProteinModelPortalQ2IH69.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290397.Adeh_4160.

Proteomic databases

PRIDEQ2IH69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC83924; ABC83924; Adeh_4160.
GeneID3887980.
KEGGade:Adeh_4160.
PATRIC20924608. VBIAnaDeh31384_4257.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAIQSSPRY.
OrthoDBEOG6Q8HXT.

Enzyme and pathway databases

BioCycADEH290397:GI2Z-4218-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_ANADE
AccessionPrimary (citable) accession number: Q2IH69
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families