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Q2IH69

- DNLI_ANADE

UniProt

Q2IH69 - DNLI_ANADE

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Protein

Probable DNA ligase

Gene
lig, Adeh_4160
Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATP By similarity
Active sitei215 – 2151N6-AMP-lysine intermediate By similarity
Binding sitei220 – 2201ATP By similarity
Binding sitei235 – 2351ATP By similarity
Binding sitei264 – 2641ATP By similarity
Binding sitei304 – 3041ATP By similarity
Binding sitei376 – 3761ATP By similarity
Binding sitei382 – 3821ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-4218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:Adeh_4160
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
Taxonomic identifieri290397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000001935: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Probable DNA ligaseUniRule annotationPRO_0000365216Add
BLAST

Proteomic databases

PRIDEiQ2IH69.

Interactioni

Protein-protein interaction databases

STRINGi290397.Adeh_4160.

Structurei

3D structure databases

ProteinModelPortaliQ2IH69.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiIQSSPRY.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2IH69-1 [UniParc]FASTAAdd to Basket

« Hide

MLLAELAEVS RAVAATPARL EKIARLADAL GRLAPDERAV GASWLAGDLP    50
GGRVGIGAAT LRAALEAAPP ERSGPGLTVA EVDAALRRIA AVAGPGSGAA 100
RRRELDALLA RAGNPERRFL AALVLGELRQ GALEGVLADA VAKAAGLPAA 150
EVRRAAMLAG ALPPVAEAAL SEGAAGLARF RLRVGEPVSP MLAQTAADVD 200
EALRALGGEA ALEWKLDGAR IQAHRDGEAV RVFSRSLRDV TAAVPEVVAL 250
LRAAPEPRLV LDGEAIALRA DGTPEPFQVT MRRFGRKLDV ERLAPELPLT 300
AFFFDALVAG GAELLARPER ERWAALARAI PAERRVPRLV TRDPAEARAF 350
LEDALARGQE GVVAKALDAP YEAGRRGAAW LKVKRAHTLD LVVLAAEWGS 400
GRRRGWLSNL HLGARDPASG GFVMLGKTFK GMTDAMLAWQ TDRLKALATG 450
PLDAWQVPVR PELVVEVAFD GIQSSPRYPG GLALRFARVK RYREDKRPED 500
ADTIETVRGL YGG 513
Length:513
Mass (Da):54,363
Last modified:March 7, 2006 - v1
Checksum:i96017811B13D10FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000251 Genomic DNA. Translation: ABC83924.1.
RefSeqiYP_467361.1. NC_007760.1.

Genome annotation databases

EnsemblBacteriaiABC83924; ABC83924; Adeh_4160.
GeneIDi3887980.
KEGGiade:Adeh_4160.
PATRICi20924608. VBIAnaDeh31384_4257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000251 Genomic DNA. Translation: ABC83924.1 .
RefSeqi YP_467361.1. NC_007760.1.

3D structure databases

ProteinModelPortali Q2IH69.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290397.Adeh_4160.

Proteomic databases

PRIDEi Q2IH69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC83924 ; ABC83924 ; Adeh_4160 .
GeneIDi 3887980.
KEGGi ade:Adeh_4160.
PATRICi 20924608. VBIAnaDeh31384_4257.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi IQSSPRY.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci ADEH290397:GI2Z-4218-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-C.

Entry informationi

Entry nameiDNLI_ANADE
AccessioniPrimary (citable) accession number: Q2IH69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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