Reviewed, UniProtKB/Swiss-Prot Q2IGX8 (ARLY_ANADE)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Adeh_4071

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Argininosuccinate lyase HAMAP MF_00006		PRO_0000240710

Sequences

	Sequence		Length	Mass (Da)
	Q2IGX8-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: A6707CE7C612F6C0	FASTA	467	50,416
	10 20 30 40 50 60 MRANSKAKPV SRAALAGEAD PRLVALSVSI QDDGALYAED IRGSQAHVSM LAAQGIVPKA 70 80 90 100 110 120 AARRIVAALD QVRAEFAAGR IRFDPALEDV HTHVERRLGE LVGKDAGYLH AGRSRNDQVA 130 140 150 160 170 180 LDERLFIVGA CDRCDAALER LQRAFLGQAR AHERTILPGY THLQRAQPVS LAHHLLAYVE 190 200 210 220 230 240 MFGRDRERFA EVRRRAAVSP LGSGALAGTT LPLDREAVAA RLGLAGVTHN SLDAVSDRDS 250 260 270 280 290 300 AAELLFACAL AAVHLSRIGE ELVLWTTKEF GFATLSDAFA TGSSLMPQKK NPDVGELARG 310 320 330 340 350 360 RAGRALGDLV ALLAILKGLP LSYNRDLQED KRPLLGGPEA LVLTADAVAG AVGTATFHAE 370 380 390 400 410 420 RMEEALGSGE ALATDAAEYL VERGVPFREA HEAVGKAAAF SAREGRPMAR LTAAEWASFH 430 440 450 460 RRFEKDVLRC FDARRSLKRR ELPGAPGPRA VRAELRRWEK ALGKARR

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC83835.1.
RefSeq	YP_467272.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IGX8.
Genome annotation databases
GeneID	3888262.
GenomeReviews	Gene locus Adeh_4071 in contig CP000251_GR.
KEGG	ade:Adeh_4071.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IGX8.
OMA	MAEDLIF.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_4071-MON.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ANADE

Accession

Primary (citable) accession number: Q2IGX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 7, 2006
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)