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Q2IG43

- TRMB_ANADE

UniProt

Q2IG43 - TRMB_ANADE

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331S-adenosyl-L-methionineUniRule annotation
Binding sitei58 – 581S-adenosyl-L-methionineUniRule annotation
Binding sitei85 – 851S-adenosyl-L-methionineUniRule annotation
Active sitei108 – 1081By similarity
Binding sitei108 – 1081S-adenosyl-L-methionineUniRule annotation
Binding sitei112 – 1121SubstrateUniRule annotation
Binding sitei144 – 1441SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-3840-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Adeh_3785
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
Taxonomic identifieri290397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001935: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201tRNA (guanine-N(7)-)-methyltransferasePRO_0000288117Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290397.Adeh_3785.

Structurei

3D structure databases

ProteinModelPortaliQ2IG43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000003597.
KOiK03439.
OMAiGFEVENS.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2IG43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFSIEDDAP IVRDLLPDWR ARFGEAGGRL ELEIGCGHGG FALGFARAFP
60 70 80 90 100
ERALVGIEQR RKFAAELAAK GARHGLSNLL VLNGDARLLA PRLFAAGSLA
110 120 130 140 150
AIHVHFPDPW WKRRHHRRRL VDDRMSALLL GLLAPGGVLD FRTDVERYAR
160 170 180 190 200
EAVVRLEEVG FRNAAGPGRF AEAAPDEIPS TRERRYLASG EPVWRLRLVK

A
Length:201
Mass (Da):22,375
Last modified:March 7, 2006 - v1
Checksum:i3A642EC0FF43E3C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC83551.1.
RefSeqiYP_466988.1. NC_007760.1.

Genome annotation databases

EnsemblBacteriaiABC83551; ABC83551; Adeh_3785.
GeneIDi3888282.
KEGGiade:Adeh_3785.
PATRICi20923819. VBIAnaDeh31384_3866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC83551.1 .
RefSeqi YP_466988.1. NC_007760.1.

3D structure databases

ProteinModelPortali Q2IG43.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290397.Adeh_3785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC83551 ; ABC83551 ; Adeh_3785 .
GeneIDi 3888282.
KEGGi ade:Adeh_3785.
PATRICi 20923819. VBIAnaDeh31384_3866.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000003597.
KOi K03439.
OMAi GFEVENS.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci ADEH290397:GI2Z-3840-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-C.

Entry informationi

Entry nameiTRMB_ANADE
AccessioniPrimary (citable) accession number: Q2IG43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3