ID   SYA_ANADE               Reviewed;         905 AA.
AC   Q2IG40;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Alanyl-tRNA synthetase;
DE            EC=6.1.1.7;
DE   AltName: Full=Alanine--tRNA ligase;
DE            Short=AlaRS;
GN   Name=alaS; OrderedLocusNames=Adeh_3784;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-alanine + tRNA(Ala) = AMP +
CC       diphosphate + L-alanyl-tRNA(Ala).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family.
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DR   EMBL; CP000251; ABC83550.1; -; Genomic_DNA.
DR   RefSeq; YP_466987.1; -.
DR   GeneID; 3888281; -.
DR   GenomeReviews; CP000251_GR; Adeh_3784.
DR   KEGG; ade:Adeh_3784; -.
DR   HOGENOM; Q2IG40; -.
DR   OMA; Q2IG40; TLMFTNS.
DR   BioCyc; ADEH290397:ADEH_3784-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004813; F:alanine-tRNA ligase activity; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006419; P:alanyl-tRNA aminoacylation; IEA:HAMAP.
DR   HAMAP; MF_00036; -; 1.
DR   InterPro; IPR002318; Ala-tRNA-synth_IIc.
DR   InterPro; IPR018165; Ala-tRNA-synth_IIc_cons-reg.
DR   InterPro; IPR018164; Ala-tRNA-synth_IIc_N.
DR   InterPro; IPR003156; Pesterase_DHHA1.
DR   InterPro; IPR012947; tRNA_SAD.
DR   Pfam; PF02272; DHHA1; 1.
DR   Pfam; PF01411; tRNA-synt_2c; 1.
DR   Pfam; PF07973; tRNA_SAD; 1.
DR   PRINTS; PR00980; TRNASYNTHALA.
DR   TIGRFAMs; TIGR00344; alaS; 1.
DR   PROSITE; PS50860; AA_TRNA_LIGASE_II_ALA; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;
KW   Ligase; Nucleotide-binding; Protein biosynthesis.
FT   CHAIN         1    905       Alanyl-tRNA synthetase.
FT                                /FTId=PRO_0000347488.
SQ   SEQUENCE   905 AA;  98444 MW;  08BB48C42CE1E0CC CRC64;
     MKTPTAAEIR ELFQRYFEEH GHRRVASSSL VPQNDPTLLF TNAGMVQFKD VFTGRERRDY
     SRATTAQKCV RAGGKHNDLE NVGFTARHHT FFEMMGNFSF GDYFKADAIA WAWELVTSPA
     WLGIAKDRLA ATVFAGEGTL PWDEEAFELW KAQGVPVERI HKLGAKDNFW AMGDTGPCGP
     CSELHYFQGN DVPCAEEQAG RKCQGVACDC DRWLEIWNLV FMQFERGQDG GLTPLPKPSI
     DTGAGLERLA AVAQGKRSNY DTDLFRSIIH AVEGLSDKRY DAASDDGVSM RVIADHARAT
     TFLVGDGVLP SNEGRGYVLR RIMRRAIRHG KRLGLERPFL AAVCGAVIDE MGAAYPETRE
     NRAFIEKVAQ QEEESFRRTL DKGLAILEGE MRKLVPDATH DGKPATPAPD RARPIIDGKV
     AFQLYDTFGF PLDLTRVIAA ERGFDVDEQG FDRHMAEQRA RSEWKGSGEQ GVDDLHKQIA
     GELGEVKFLG YELPAARAQV KAILANGARV ARAGKGDKVE IVTDATPFYG ESGGQVGDVG
     HITGAGLEIR VDDAQRPVPG LVTHVGEVLR GEVAVGDAVE LSVDDRRRDL VRANHSATHL
     LQLALREVLG EHVKQAGSVV APDYLRFDFS HFQPVTEEEL AAVERRVNEL VRENAETETA
     VLKLEEARHA GAMMIFGEKY GDVVRVVRIG PSKELCGGTH VRRSGDIAFF KIGSEESIAS
     GVRRLVAYTG ARAVEVQQRE AEELRRAAAL LKAGALEVSQ KIEQTQRRVK DLERALEEAR
     SKAAAAQSGD LAALAKDVGG AKVLAARVEG DGKALRELAD KLRDRLGKGV VALGAEQDGK
     AILLVAVTRD LTARLKAGDL VKEAAKLVGG SGGGKPDMAQ AGGSDPAGLE KALEKVAELA
     ARALA
//