Reviewed, UniProtKB/Swiss-Prot Q2IG26 (MRAY_ANADE)

Names and origin

Protein names

Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
    EC=2.7.8.13
Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferase

Gene names

Name:	mraY
Ordered Locus Names:	Adeh_3768

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity.
Catalytic activity	UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 4 family. MraY subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	phospho-N-acetylmuramoyl-pentapeptide-transferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038		PRO_0000235436
Regions
	Transmembrane	26 – 46	21	Potential
	Transmembrane	75 – 95	21	Potential
	Transmembrane	98 – 118	21	Potential
	Transmembrane	135 – 155	21	Potential
	Transmembrane	161 – 181	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	222 – 242	21	Potential
	Transmembrane	259 – 279	21	Potential
	Transmembrane	283 – 303	21	Potential
	Transmembrane	311 – 331	21	Potential
	Transmembrane	357 – 377	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2IG26-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 972FD62179452299	FASTA	380	41,679
	10 20 30 40 50 60 MLYHLLYPLA YKLSLLNVLR YPSFRIVAAG LTAMVLGLLL GPIFIERMRV LQYGSTNVRE 70 80 90 100 110 120 DTPDTHKKKA GTPSMGGALI LASVAIATLL FADLANRFVW AALLVTLGYG AIGFTDDWLK 130 140 150 160 170 180 ISKKNSKGLA GKKKLVLQVL VVVVVYYACL TDWRFHVEHR FPWVFVGSYV DLHVTLPFVP 190 200 210 220 230 240 SRLFNPDLGF LYLPFMVFVV IATSNAVNLT DGLDGLAIGP TVVSAMTFLA LSYVAGATIA 250 260 270 280 290 300 GFSLAEYLRV PYIPGAEELG VFCSAIFGAG VAFLWYNTYP ASVFMGDVGS LALGGGLGMM 310 320 330 340 350 360 AVLTKNEFAS AILHGVFLTE TVSVILQVWS FKTTGKRIFR MAPIHHHYEL KGWAEPKIIV 370 380 RFWIISVMLA LVALLSIKLR

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC83534.1.
RefSeq	YP_466971.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IG26.
Genome annotation databases
GeneID	3886504.
GenomeReviews	Gene locus Adeh_3768 in contig CP000251_GR.
KEGG	ade:Adeh_3768.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IG26.
OMA	HHHFEQK.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_3768-MON.
Family and domain databases
HAMAP	MF_00038. [Tree]
InterPro	IPR000715. Glycosyl_transferase_4. IPR018481. Glycosyl_Trfase_4_cons-reg. IPR003524. PNAcMuramoyl-5peptid_Trfase. IPR018480. PNAcMuramoyl-5peptid_Trfase_CS. [Graphical view]
PANTHER	PTHR22926. Glyco_trans_4. 1 hit. PTHR22926:SF3. PNAcPpept_trans. 1 hit.
Pfam	PF00953. Glycos_transf_4. 1 hit. PF10555. MraY_sig1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00445. mraY. 1 hit.
PROSITE	PS01347. MRAY_1. 1 hit. PS01348. MRAY_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MRAY_ANADE

Accession

Primary (citable) accession number: Q2IG26

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	March 7, 2006
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)