Reviewed, UniProtKB/Swiss-Prot Q2IFU7 (GCP_ANADE)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Adeh_3687

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable. HAMAP MF_01445
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303254
Sites
	Metal binding	112	1	Zinc Potential
	Metal binding	116	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2IFU7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: E4968D370BB49B99	FASTA	334	34,884
	10 20 30 40 50 60 MTRVLAIETS CDETAAAVVE DGRRALSDVV STQIDIHRRW GGVVPELASR NHVVQVMPVV 70 80 90 100 110 120 DEALTRSGVG PEGLDAVAVT SGPGLVGALL VGVQAAKALA LAWGKPLVGV NHLEGHLVAA 130 140 150 160 170 180 FLAEVPPAFP YLGLVVSGGH TSLYAAHGFG DYRLLGQTRD DAAGEAFDKG AKLLGLPYPG 190 200 210 220 230 240 GVAIDRLAKE GDPAAIRFPK AIVKGADLDF SFSGLKTALL HHVKKHGVPE GPALADLCAS 250 260 270 280 290 300 YQEAIVRALV EKAFRAARRL QFERLVLAGG VAANSRLRAA ATARAAEYEG MSVFIPPVRL 310 320 330 CTDNAAMIAV AGTHALLRGE RAGPDLNADP AWRL

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000251 Genomic DNA. Translation: ABC83453.1.
RefSeq	YP_466890.1.
3D structure databases
SMR	Q2IFU7. Positions 3-334.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2IFU7.
Genome annotation databases
GeneID	3886462.
GenomeReviews	Gene locus Adeh_3687 in contig CP000251_GR.
KEGG	ade:Adeh_3687.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0533.
HOGENOM	HBG304663.
OMA	CKRALKQ.
PhylomeDB	Q2IFU7.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_3687-MONOMER.
Family and domain databases
HAMAP	MF_01445. Glycoptase_bact. [Tree]
InterPro	IPR009180. Pept_M22_O-sialoglycoprot. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ANADE

Accession

Primary (citable) accession number: Q2IFU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 7, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)