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Q2IFU3

- PANC_ANADE

UniProt

Q2IFU3 - PANC_ANADE

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Protein

Pantothenate synthetase

Gene

panC

Organism
Anaeromyxobacter dehalogenans (strain 2CP-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton donorUniRule annotation
Binding sitei70 – 701Beta-alanineUniRule annotation
Binding sitei70 – 701PantoateUniRule annotation
Binding sitei163 – 1631PantoateUniRule annotation
Binding sitei186 – 1861ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 408ATPUniRule annotation
Nucleotide bindingi157 – 1604ATPUniRule annotation
Nucleotide bindingi194 – 1974ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciADEH290397:GI2Z-3736-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Adeh_3681
OrganismiAnaeromyxobacter dehalogenans (strain 2CP-C)
Taxonomic identifieri290397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001935: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Pantothenate synthetasePRO_0000305390Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290397.Adeh_3681.

Structurei

3D structure databases

ProteinModelPortaliQ2IFU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiIVRDSDH.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2IFU3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTPELITDP AAWQARCTAA REAGTRIALV TTMGYLHEGH LSLMREARRR
60 70 80 90 100
ADAGGRRGLA VGTIFVNPTQ FGPTEDLARY PRDLEGDLAK CAAAGLDAVL
110 120 130 140 150
APSDPALMFA PGHETWVTVE RASQGLDGAS RPGHFRGVAT VVAKLFNLTR
160 170 180 190 200
PHVALFGEKD WQQLAVIRAM VRDLAFGIEI VGMPIVREPD GLALSSRNAY
210 220 230 240 250
LSPDERRRAL ALSGALAEAR EATARGERDA AALRAGARAR LEAAGGRVDY
260 270 280
VELVHPETLA PVARAEPGTV LLLAASFGTT RLIDNGRLP
Length:289
Mass (Da):30,882
Last modified:March 7, 2006 - v1
Checksum:iF55FC51F1DA2F117
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC83447.1.
RefSeqiWP_011422729.1. NC_007760.1.
YP_466884.1. NC_007760.1.

Genome annotation databases

EnsemblBacteriaiABC83447; ABC83447; Adeh_3681.
GeneIDi3886456.
KEGGiade:Adeh_3681.
PATRICi20923607. VBIAnaDeh31384_3760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000251 Genomic DNA. Translation: ABC83447.1 .
RefSeqi WP_011422729.1. NC_007760.1.
YP_466884.1. NC_007760.1.

3D structure databases

ProteinModelPortali Q2IFU3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290397.Adeh_3681.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC83447 ; ABC83447 ; Adeh_3681 .
GeneIDi 3886456.
KEGGi ade:Adeh_3681.
PATRICi 20923607. VBIAnaDeh31384_3760.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi IVRDSDH.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci ADEH290397:GI2Z-3736-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2CP-C.

Entry informationi

Entry nameiPANC_ANADE
AccessioniPrimary (citable) accession number: Q2IFU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3